Mathematical modeling has been very instrumental in aiding traditional experimental methods in uncovering the mysteries of actin dynamics. Here we review recent quantitative models of actin dynamics focusing on ATPATP hydrolysishydrolysis effects, forceforce generation by single actin filaments and networks, self-organization and dynamics of actin networks, dynamics of lamellipodialamellipodia, filopodia and lamella, and integrative mechanochemistry of whole motile cells. We discuss both modeling methods and specific insights from modeling that helped answering biological questions.
|Original language||English (US)|
|Title of host publication||Actin-based Motility|
|Subtitle of host publication||Cellular, Molecular and Physical Aspects|
|Number of pages||32|
|State||Published - 2010|
ASJC Scopus subject areas