Mathematical and physical modeling of actin dynamics in motile cells

Anders E. Carlsson, Alex Mogilner

Research output: Chapter in Book/Report/Conference proceedingChapter


Mathematical modeling has been very instrumental in aiding traditional experimental methods in uncovering the mysteries of actin dynamics. Here we review recent quantitative models of actin dynamics focusing on ATPATP hydrolysishydrolysis effects, forceforce generation by single actin filaments and networks, self-organization and dynamics of actin networks, dynamics of lamellipodialamellipodia, filopodia and lamella, and integrative mechanochemistry of whole motile cells. We discuss both modeling methods and specific insights from modeling that helped answering biological questions.

Original languageEnglish (US)
Title of host publicationActin-based Motility
Subtitle of host publicationCellular, Molecular and Physical Aspects
PublisherSpringer Netherlands
Number of pages32
ISBN (Electronic)9789048193011
ISBN (Print)9789048193004
StatePublished - 2010

ASJC Scopus subject areas

  • General Medicine


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