Maximal testosterone suppression in prostate cancer - Free vs total testosterone

Kyle O. Rove; E. David Crawford; Massimo Perachino; Juan Morote; Laurence Klotz; Paul H. Lange; Gerald L. Andriole; Alvin M. Matsumoto; Samir S. Taneja; Mario A. Eisenberger; Leonardo O. Reis

doi:10.1016/j.urology.2014.02.001

Maximal testosterone suppression in prostate cancer - Free vs total testosterone

Kyle O. Rove, E. David Crawford, Massimo Perachino, Juan Morote, Laurence Klotz, Paul H. Lange, Gerald L. Andriole, Alvin M. Matsumoto, Samir S. Taneja, Mario A. Eisenberger, Leonardo O. Reis

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Testosterone remains a key target in the treatment of advanced prostate cancer. The relationship of free testosterone to prostate cancer treatment and outcomes remains largely unexplored. A consensus of prostate cancer experts was convened in 2013 to review current knowledge surrounding relationship of total and free testosterone to prostate cancer, discuss the free hormone hypothesis, and highlight future avenues for therapeutics. Free testosterone may better reflect prostate cancer tissue androgen levels than serum total testosterone concentration. Free testosterone deserves more research regarding its relation to clinical outcomes.

Original language	English (US)
Pages (from-to)	1217-1222
Number of pages	6
Journal	Urology
Volume	83
Issue number	6
DOIs	https://doi.org/10.1016/j.urology.2014.02.001
State	Published - Jun 2014

ASJC Scopus subject areas

Urology

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10.1016/j.urology.2014.02.001

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title = "Maximal testosterone suppression in prostate cancer - Free vs total testosterone",

abstract = "Testosterone remains a key target in the treatment of advanced prostate cancer. The relationship of free testosterone to prostate cancer treatment and outcomes remains largely unexplored. A consensus of prostate cancer experts was convened in 2013 to review current knowledge surrounding relationship of total and free testosterone to prostate cancer, discuss the free hormone hypothesis, and highlight future avenues for therapeutics. Free testosterone may better reflect prostate cancer tissue androgen levels than serum total testosterone concentration. Free testosterone deserves more research regarding its relation to clinical outcomes.",

author = "Rove, {Kyle O.} and Crawford, {E. David} and Massimo Perachino and Juan Morote and Laurence Klotz and Lange, {Paul H.} and Andriole, {Gerald L.} and Matsumoto, {Alvin M.} and Taneja, {Samir S.} and Eisenberger, {Mario A.} and Reis, {Leonardo O.}",

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AU - Rove, Kyle O.

AU - Crawford, E. David

AU - Perachino, Massimo

AU - Morote, Juan

AU - Klotz, Laurence

AU - Lange, Paul H.

AU - Andriole, Gerald L.

AU - Matsumoto, Alvin M.

AU - Taneja, Samir S.

AU - Eisenberger, Mario A.

AU - Reis, Leonardo O.

PY - 2014/6

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N2 - Testosterone remains a key target in the treatment of advanced prostate cancer. The relationship of free testosterone to prostate cancer treatment and outcomes remains largely unexplored. A consensus of prostate cancer experts was convened in 2013 to review current knowledge surrounding relationship of total and free testosterone to prostate cancer, discuss the free hormone hypothesis, and highlight future avenues for therapeutics. Free testosterone may better reflect prostate cancer tissue androgen levels than serum total testosterone concentration. Free testosterone deserves more research regarding its relation to clinical outcomes.

AB - Testosterone remains a key target in the treatment of advanced prostate cancer. The relationship of free testosterone to prostate cancer treatment and outcomes remains largely unexplored. A consensus of prostate cancer experts was convened in 2013 to review current knowledge surrounding relationship of total and free testosterone to prostate cancer, discuss the free hormone hypothesis, and highlight future avenues for therapeutics. Free testosterone may better reflect prostate cancer tissue androgen levels than serum total testosterone concentration. Free testosterone deserves more research regarding its relation to clinical outcomes.

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Maximal testosterone suppression in prostate cancer - Free vs total testosterone

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ASJC Scopus subject areas

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