May the force be with you (Or not): The immune system under microgravity

Mei Elgindi; Jiranuwat Sapudom; Ibrahim Hamed Ibrahim; Mohamed Al-Sayegh; Weiqiang Chen; Anna Garcia-Sabaté; Jeremy C.M. Teo

doi:10.3390/cells10081941

May the force be with you (Or not): The immune system under microgravity

Mei Elgindi, Jiranuwat Sapudom, Ibrahim Hamed Ibrahim, Mohamed Al-Sayegh, Weiqiang Chen, Anna Garcia-Sabaté, Jeremy C.M. Teo

Research output: Contribution to journal › Letter › peer-review

Abstract

All terrestrial organisms have evolved and adapted to thrive under Earth’s gravitational force. Due to the increase of crewed space flights in recent years, it is vital to understand how the lack of gravitational forces affects organisms. It is known that astronauts who have been exposed to microgravity suffer from an array of pathological conditions including an impaired immune system, which is one of the most negatively affected by microgravity. However, at the cellular level a gap in knowledge exists, limiting our ability to understand immune impairment in space. This review highlights the most significant work done over the past 10 years detailing the effects of microgravity on cellular aspects of the immune system.

Original language	English (US)
Article number	1941
Journal	Cells
Volume	10
Issue number	8
DOIs	https://doi.org/10.3390/cells10081941
State	Published - Aug 2021

Keywords

Immune cells
Immunology
Mechanotransduction
Microgravity
Space biology
Space research

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.3390/cells10081941

Cite this

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title = "May the force be with you (Or not): The immune system under microgravity",

abstract = "All terrestrial organisms have evolved and adapted to thrive under Earth{\textquoteright}s gravitational force. Due to the increase of crewed space flights in recent years, it is vital to understand how the lack of gravitational forces affects organisms. It is known that astronauts who have been exposed to microgravity suffer from an array of pathological conditions including an impaired immune system, which is one of the most negatively affected by microgravity. However, at the cellular level a gap in knowledge exists, limiting our ability to understand immune impairment in space. This review highlights the most significant work done over the past 10 years detailing the effects of microgravity on cellular aspects of the immune system.",

keywords = "Immune cells, Immunology, Mechanotransduction, Microgravity, Space biology, Space research",

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AU - Elgindi, Mei

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AU - Al-Sayegh, Mohamed

AU - Chen, Weiqiang

AU - Garcia-Sabaté, Anna

AU - Teo, Jeremy C.M.

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AB - All terrestrial organisms have evolved and adapted to thrive under Earth’s gravitational force. Due to the increase of crewed space flights in recent years, it is vital to understand how the lack of gravitational forces affects organisms. It is known that astronauts who have been exposed to microgravity suffer from an array of pathological conditions including an impaired immune system, which is one of the most negatively affected by microgravity. However, at the cellular level a gap in knowledge exists, limiting our ability to understand immune impairment in space. This review highlights the most significant work done over the past 10 years detailing the effects of microgravity on cellular aspects of the immune system.

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May the force be with you (Or not): The immune system under microgravity

Abstract

Keywords

ASJC Scopus subject areas

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