Measures for validation of DTI tractography

Sylvain Gouttard, Casey B. Goodlett, Marek Kubicki, Guido Gerig

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    The evaluation of analysis methods for diffusion tensor imaging (DTI) remains challenging due to the lack of gold standards and validation frameworks. Significant work remains in developing metrics for comparing fiber bundles generated from streamline tractography. We propose a set of volumetric and tract oriented measures for evaluating tract differences. The different methodsdeveloped for this assessment work are: an overlap measurement, a point cloud distance and a quantification of the diffusion properties at similar locations between fiber bundles. The application of the measures in this paper is a comparison of atlas generated tractography to tractography generated in individual images. For the validation we used a database of 37 subject DTIs, and applied the measurements on five specific fiber bundles: uncinate, cingulum (left and right for both bundles) and genu. Each measurments is interesting for specific use: the overlap measure presents a simple and comprehensive metric but is sensitive to partial voluming and does not give consistent values depending on the bundle geometry. The point cloud distance associated with a quantile interpretation of the distribution gives a good intuition of how close and similar the bundles are. Finally, the functional difference is useful for a comparison of the diffusion properties since it is the focus of many DTI analysis to compare scalar invariants. The comparison demonstrated reasonable similarity of results. The tract difference measures are also applicable to comparison of tractography algorithms, quality control, reproducibility studies, and other validation problems.

    Original languageEnglish (US)
    Title of host publicationMedical Imaging 2012
    Subtitle of host publicationImage Processing
    DOIs
    StatePublished - 2012
    EventMedical Imaging 2012: Image Processing - San Diego, CA, United States
    Duration: Feb 6 2012Feb 9 2012

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume8314
    ISSN (Print)1605-7422

    Other

    OtherMedical Imaging 2012: Image Processing
    CountryUnited States
    CitySan Diego, CA
    Period2/6/122/9/12

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Radiology Nuclear Medicine and imaging

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  • Cite this

    Gouttard, S., Goodlett, C. B., Kubicki, M., & Gerig, G. (2012). Measures for validation of DTI tractography. In Medical Imaging 2012: Image Processing [83140J] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8314). https://doi.org/10.1117/12.911546