Mechanisms of cancer pain

Brian L. Schmidt; Darryl T. Hamamoto; Donald A. Simone; George L. Wilcox

doi:10.1124/mi.10.3.7

Mechanisms of cancer pain

Brian L. Schmidt, Darryl T. Hamamoto, Donald A. Simone, George L. Wilcox

Oral and Maxillofacial Surgery

Research output: Contribution to journal › Review article › peer-review

Abstract

Cancer pain is a formidable clinical problem, reflecting a complex series of cellular, tissue, and systemic changes that occur during proliferation, invasion, and metastasis. Primary afferent nociceptors are modulated by a number of mediators released by cancer cells, and immune cells that are drawn into the cancer further complicate pain perception. The peripheral neuropathic changes and the influence of tumors upon neurons in the elaboration of pain and central sensitization are beginning to be understood in some detail. The judicious design and exploitation of animal models continue to help researchers unravel the complexities of cancer-evoked pain.

Original language	English (US)
Pages (from-to)	164-178
Number of pages	15
Journal	Molecular Interventions
Volume	10
Issue number	3
DOIs	https://doi.org/10.1124/mi.10.3.7
State	Published - Jun 2010

ASJC Scopus subject areas

Molecular Medicine

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10.1124/mi.10.3.7

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title = "Mechanisms of cancer pain",

abstract = "Cancer pain is a formidable clinical problem, reflecting a complex series of cellular, tissue, and systemic changes that occur during proliferation, invasion, and metastasis. Primary afferent nociceptors are modulated by a number of mediators released by cancer cells, and immune cells that are drawn into the cancer further complicate pain perception. The peripheral neuropathic changes and the influence of tumors upon neurons in the elaboration of pain and central sensitization are beginning to be understood in some detail. The judicious design and exploitation of animal models continue to help researchers unravel the complexities of cancer-evoked pain.",

author = "Schmidt, {Brian L.} and Hamamoto, {Darryl T.} and Simone, {Donald A.} and Wilcox, {George L.}",

year = "2010",

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AU - Simone, Donald A.

AU - Wilcox, George L.

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N2 - Cancer pain is a formidable clinical problem, reflecting a complex series of cellular, tissue, and systemic changes that occur during proliferation, invasion, and metastasis. Primary afferent nociceptors are modulated by a number of mediators released by cancer cells, and immune cells that are drawn into the cancer further complicate pain perception. The peripheral neuropathic changes and the influence of tumors upon neurons in the elaboration of pain and central sensitization are beginning to be understood in some detail. The judicious design and exploitation of animal models continue to help researchers unravel the complexities of cancer-evoked pain.

AB - Cancer pain is a formidable clinical problem, reflecting a complex series of cellular, tissue, and systemic changes that occur during proliferation, invasion, and metastasis. Primary afferent nociceptors are modulated by a number of mediators released by cancer cells, and immune cells that are drawn into the cancer further complicate pain perception. The peripheral neuropathic changes and the influence of tumors upon neurons in the elaboration of pain and central sensitization are beginning to be understood in some detail. The judicious design and exploitation of animal models continue to help researchers unravel the complexities of cancer-evoked pain.

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VL - 10

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JO - Molecular Interventions

JF - Molecular Interventions

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Mechanisms of cancer pain

Abstract

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