Mechanisms of HTLV-1 transformation.

Kylene Kehn, Reem Berro, Cynthia de la Fuente, Katharine Strouss, Elodie Ghedin, Shabnam Dadgar, Maria Elena Bottazzi, Anne Pumfery, Fatah Kashanchi

Research output: Contribution to journalReview articlepeer-review


HTLV-1 is the etiological agent of the fatal disease adult T-cell leukemia. The virus encodes many proteins including several accessory proteins, p12I, p13II, p27I, and p30II, whose roles have recently begun to be elucidated. These accessory proteins are important in T-cell activation, transcriptional regulation, viral persistence, and virus assembly. The viral oncogene Tax is thought to be largely responsible for tumorigenesis, although the precise mechanisms underlying transformation are not completely understood. Tax has a profound impact on transcription, cell growth regulation, genomic stability and apoptosis. This review will provide possible contributions of the accessory proteins to transformation as well as highlight the alterations of the above-mentioned cellular events by Tax. Animal models of both Tax and the accessory proteins are also included based on the essential information on the transformation process in vivo that they provide.

Original languageEnglish (US)
Pages (from-to)2347-2372
Number of pages26
JournalFrontiers in bioscience : a journal and virtual library
StatePublished - 2004

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology


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