Mechanisms of X chromosome dosage compensation

Research output: Contribution to journalReview article

Abstract

In many animals, males have one X and females have two X chromosomes. The difference in X chromosome dosage between the two sexes is compensated by mechanisms that regulate X chromosome transcription. Recent advances in genomic techniques have provided new insights into the molecular mechanisms of X chromosome dosage compensation. In this review, I summarize our current understanding of dosage imbalance in general, and then review the molecular mechanisms of X chromosome dosage compensation with an emphasis on the parallels and differences between the three well-studied model systems, M. musculus, D. melanogaster and C. elegans.

Original languageEnglish (US)
Pages (from-to)1-19
Number of pages19
JournalJournal of Genomics
Volume3
DOIs
StatePublished - Jan 1 2015

Keywords

  • Mechanisms
  • X chromosomes

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

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