Mechanistic insights from reversible splicing catalysis

Duncan J. Smith, Maria M. Konarska

Research output: Contribution to journalReview article

Abstract

Recent work demonstrating the ability of spliceosomes purified after the second catalytic step of splicing to efficiently reverse both steps of the reaction provides answers to several unresolved questions regarding the splicing reaction, and raises many more.

Original languageEnglish (US)
Pages (from-to)1975-1978
Number of pages4
JournalRNA
Volume14
Issue number10
DOIs
StatePublished - Oct 2008

Keywords

  • ATPases
  • Active site
  • Conformational toggling
  • Reversible splicing
  • Spliced exon reopening

ASJC Scopus subject areas

  • Molecular Biology

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