Mechanistic insights from reversible splicing catalysis

Duncan J. Smith, Maria M. Konarska

Research output: Contribution to journalReview articlepeer-review


Recent work demonstrating the ability of spliceosomes purified after the second catalytic step of splicing to efficiently reverse both steps of the reaction provides answers to several unresolved questions regarding the splicing reaction, and raises many more.

Original languageEnglish (US)
Pages (from-to)1975-1978
Number of pages4
Issue number10
StatePublished - Oct 2008


  • ATPases
  • Active site
  • Conformational toggling
  • Reversible splicing
  • Spliced exon reopening

ASJC Scopus subject areas

  • Molecular Biology

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