Abstract
Recent work demonstrating the ability of spliceosomes purified after the second catalytic step of splicing to efficiently reverse both steps of the reaction provides answers to several unresolved questions regarding the splicing reaction, and raises many more.
Original language | English (US) |
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Pages (from-to) | 1975-1978 |
Number of pages | 4 |
Journal | RNA |
Volume | 14 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2008 |
Keywords
- ATPases
- Active site
- Conformational toggling
- Reversible splicing
- Spliced exon reopening
ASJC Scopus subject areas
- Molecular Biology