Mechanosensation: Capping actin filaments for robustness

Alex Mogilner; Christopher E. Miles

doi:10.1016/j.cub.2022.09.025

Mechanosensation: Capping actin filaments for robustness

Alex Mogilner, Christopher E. Miles

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Actin networks adapt to resistance by becoming denser. A recent investigation shows that this mechanosensation relies on a force-sensitive mechanical ratchet of capping actin filaments to reorganize the network. This and other mechanical feedback mechanisms make actin-based protrusion amazingly robust.

Original language	English (US)
Pages (from-to)	R1033-R1035
Journal	Current Biology
Volume	32
Issue number	20
DOIs	https://doi.org/10.1016/j.cub.2022.09.025
State	Published - Oct 24 2022

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

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10.1016/j.cub.2022.09.025

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@article{f0cbea5b2baf4c45803edea5566872c5,

title = "Mechanosensation: Capping actin filaments for robustness",

abstract = "Actin networks adapt to resistance by becoming denser. A recent investigation shows that this mechanosensation relies on a force-sensitive mechanical ratchet of capping actin filaments to reorganize the network. This and other mechanical feedback mechanisms make actin-based protrusion amazingly robust.",

author = "Alex Mogilner and Miles, {Christopher E.}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

month = oct,

day = "24",

doi = "10.1016/j.cub.2022.09.025",

language = "English (US)",

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journal = "Current Biology",

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T1 - Mechanosensation

T2 - Capping actin filaments for robustness

AU - Mogilner, Alex

AU - Miles, Christopher E.

PY - 2022/10/24

Y1 - 2022/10/24

N2 - Actin networks adapt to resistance by becoming denser. A recent investigation shows that this mechanosensation relies on a force-sensitive mechanical ratchet of capping actin filaments to reorganize the network. This and other mechanical feedback mechanisms make actin-based protrusion amazingly robust.

AB - Actin networks adapt to resistance by becoming denser. A recent investigation shows that this mechanosensation relies on a force-sensitive mechanical ratchet of capping actin filaments to reorganize the network. This and other mechanical feedback mechanisms make actin-based protrusion amazingly robust.

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U2 - 10.1016/j.cub.2022.09.025

DO - 10.1016/j.cub.2022.09.025

M3 - Comment/debate

C2 - 36283352

AN - SCOPUS:85140225127

SN - 0960-9822

VL - 32

SP - R1033-R1035

JO - Current Biology

JF - Current Biology

IS - 20

ER -

Mechanosensation: Capping actin filaments for robustness

Abstract

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