Mechanosensation: Capping actin filaments for robustness

Alex Mogilner, Christopher E. Miles

Research output: Contribution to journalComment/debatepeer-review


Actin networks adapt to resistance by becoming denser. A recent investigation shows that this mechanosensation relies on a force-sensitive mechanical ratchet of capping actin filaments to reorganize the network. This and other mechanical feedback mechanisms make actin-based protrusion amazingly robust.

Original languageEnglish (US)
Pages (from-to)R1033-R1035
JournalCurrent Biology
Issue number20
StatePublished - Oct 24 2022

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences


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