TY - JOUR
T1 - Mediterranean diet and white matter hyperintensity volume in the Northern Manhattan study
AU - Gardener, Hannah
AU - Scarmeas, Nikolaos
AU - Gu, Yian
AU - Boden-Albala, Bernadette
AU - Elkind, Mitchell S V
AU - Sacco, Ralph L.
AU - DeCarli, Charles
AU - Wright, Clinton B.
PY - 2012/2
Y1 - 2012/2
N2 - Objective: To examine the association between a Mediterranean-style diet (MeDi) and brain magnetic resonance imaging white matter hyperintensity volume (WMHV). Design: A cross-sectional analysis within a longitudinal population-based cohort study. A semiquantitative food frequency questionnaire was administered, and a score (range, 0-9) was calculated to reflect increasing similarity to the MeDi pattern. Setting: The Northern Manhattan Study. Participants: A total of 1091 participants, of whom 966 had dietary information (mean age, 72 years; 59.3% women, 64.6% Hispanic, 15.6% white, and 17.5% black). Main Outcome Measures: The WMHV was measured by quantitative brain magnetic resonance imaging. Linear regression models were constructed to examine the association between the MeDi score and the log-transformed WMHV as a proportion of total cranial volume, controlling for sociodemographic and vascular risk factors. Results: On the MeDi scale, 11.6% scored 0 to 2, 15.8% scored 3, 23.0% scored 4, 23.5% scored 5, and 26.1% scored 6 to 9. Each 1-point increase in MeDi score was associated with a lower log WMHV (β=-.04, P=.01). The only MeDi score component that was an independent predictor of WMHV was the ratio of monounsaturated to saturated fat (β=-.20, P=.001). Conclusions: A MeDi was associated with a lower WMHV burden, a marker of small vessel damage in the brain. However, white matter hyperintensities are etiologically heterogenous and can include neurodegeneration. Replication by other population-based studies is needed.
AB - Objective: To examine the association between a Mediterranean-style diet (MeDi) and brain magnetic resonance imaging white matter hyperintensity volume (WMHV). Design: A cross-sectional analysis within a longitudinal population-based cohort study. A semiquantitative food frequency questionnaire was administered, and a score (range, 0-9) was calculated to reflect increasing similarity to the MeDi pattern. Setting: The Northern Manhattan Study. Participants: A total of 1091 participants, of whom 966 had dietary information (mean age, 72 years; 59.3% women, 64.6% Hispanic, 15.6% white, and 17.5% black). Main Outcome Measures: The WMHV was measured by quantitative brain magnetic resonance imaging. Linear regression models were constructed to examine the association between the MeDi score and the log-transformed WMHV as a proportion of total cranial volume, controlling for sociodemographic and vascular risk factors. Results: On the MeDi scale, 11.6% scored 0 to 2, 15.8% scored 3, 23.0% scored 4, 23.5% scored 5, and 26.1% scored 6 to 9. Each 1-point increase in MeDi score was associated with a lower log WMHV (β=-.04, P=.01). The only MeDi score component that was an independent predictor of WMHV was the ratio of monounsaturated to saturated fat (β=-.20, P=.001). Conclusions: A MeDi was associated with a lower WMHV burden, a marker of small vessel damage in the brain. However, white matter hyperintensities are etiologically heterogenous and can include neurodegeneration. Replication by other population-based studies is needed.
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U2 - 10.1001/archneurol.2011.548
DO - 10.1001/archneurol.2011.548
M3 - Article
C2 - 22332193
AN - SCOPUS:84856908293
SN - 0003-9942
VL - 69
SP - 251
EP - 256
JO - Archives of Neurology
JF - Archives of Neurology
IS - 2
ER -