Mediterranean diet and white matter hyperintensity volume in the Northern Manhattan study

Hannah Gardener, Nikolaos Scarmeas, Yian Gu, Bernadette Boden-Albala, Mitchell S V Elkind, Ralph L. Sacco, Charles DeCarli, Clinton B. Wright

Research output: Contribution to journalArticlepeer-review


Objective: To examine the association between a Mediterranean-style diet (MeDi) and brain magnetic resonance imaging white matter hyperintensity volume (WMHV). Design: A cross-sectional analysis within a longitudinal population-based cohort study. A semiquantitative food frequency questionnaire was administered, and a score (range, 0-9) was calculated to reflect increasing similarity to the MeDi pattern. Setting: The Northern Manhattan Study. Participants: A total of 1091 participants, of whom 966 had dietary information (mean age, 72 years; 59.3% women, 64.6% Hispanic, 15.6% white, and 17.5% black). Main Outcome Measures: The WMHV was measured by quantitative brain magnetic resonance imaging. Linear regression models were constructed to examine the association between the MeDi score and the log-transformed WMHV as a proportion of total cranial volume, controlling for sociodemographic and vascular risk factors. Results: On the MeDi scale, 11.6% scored 0 to 2, 15.8% scored 3, 23.0% scored 4, 23.5% scored 5, and 26.1% scored 6 to 9. Each 1-point increase in MeDi score was associated with a lower log WMHV (β=-.04, P=.01). The only MeDi score component that was an independent predictor of WMHV was the ratio of monounsaturated to saturated fat (β=-.20, P=.001). Conclusions: A MeDi was associated with a lower WMHV burden, a marker of small vessel damage in the brain. However, white matter hyperintensities are etiologically heterogenous and can include neurodegeneration. Replication by other population-based studies is needed.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalArchives of Neurology
Issue number2
StatePublished - Feb 2012

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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