TY - JOUR
T1 - Meeting report
T2 - The role of the mobilome in cancer
AU - Ardeljan, Daniel
AU - Taylor, Martin S.
AU - Burns, Kathleen H.
AU - Boeke, Jef D.
AU - Espey, Michael Graham
AU - Woodhouse, Elisa C.
AU - Howcroft, Thomas Kevin
N1 - Publisher Copyright:
©2016 AACR.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Approximately half of the human genome consists of repetitive sequence attributed to the activities of mobile DNAs, including DNA transposons, RNA transposons, and endogenous retro-viruses. Of these, only long interspersed elements (LINE-1 or L1) and sequences copied by LINE-1 remain mobile in our species today. Although cells restrict L1 activity by both transcriptional and posttranscriptional mechanisms, L1 derepression occurs in developmental and pathologic contexts, including many types of cancers. However, we have limited knowledge of the extent and consequences of L1 expression in premalignancies and cancer. Participants in this NIH strategic workshop considered key questions to enhance our understanding of mechanisms and roles the mobilome may play in cancer biology.
AB - Approximately half of the human genome consists of repetitive sequence attributed to the activities of mobile DNAs, including DNA transposons, RNA transposons, and endogenous retro-viruses. Of these, only long interspersed elements (LINE-1 or L1) and sequences copied by LINE-1 remain mobile in our species today. Although cells restrict L1 activity by both transcriptional and posttranscriptional mechanisms, L1 derepression occurs in developmental and pathologic contexts, including many types of cancers. However, we have limited knowledge of the extent and consequences of L1 expression in premalignancies and cancer. Participants in this NIH strategic workshop considered key questions to enhance our understanding of mechanisms and roles the mobilome may play in cancer biology.
UR - http://www.scopus.com/inward/record.url?scp=84982746869&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84982746869&partnerID=8YFLogxK
U2 - 10.1158/0008-5472.CAN-15-3421
DO - 10.1158/0008-5472.CAN-15-3421
M3 - Article
C2 - 27527733
AN - SCOPUS:84982746869
SN - 0008-5472
VL - 76
SP - 4316
EP - 4319
JO - Cancer Research
JF - Cancer Research
IS - 15
ER -