Meiosis: A PRDM9 Guide to the Hotspots of Recombination

Andreas Hochwagen, Gabriel A A.B. Marais

Research output: Contribution to journalShort surveypeer-review


During meiosis, homologous recombination occurs preferentially at defined hotspots. In mammals, the fast-evolving DNA-binding domain of PRDM9 has now been identified as a major hotspot determinant that may explain the rapid rates of hotspot redistribution during evolution.

Original languageEnglish (US)
Pages (from-to)R271-R274
JournalCurrent Biology
Issue number6
StatePublished - Mar 23 2010

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences


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