Meiosis: A PRDM9 Guide to the Hotspots of Recombination

Andreas Hochwagen; Gabriel A A.B. Marais

doi:10.1016/j.cub.2010.01.048

Meiosis: A PRDM9 Guide to the Hotspots of Recombination

Andreas Hochwagen, Gabriel A A.B. Marais

Biology and Genomics

Research output: Contribution to journal › Short survey › peer-review

Abstract

During meiosis, homologous recombination occurs preferentially at defined hotspots. In mammals, the fast-evolving DNA-binding domain of PRDM9 has now been identified as a major hotspot determinant that may explain the rapid rates of hotspot redistribution during evolution.

Original language	English (US)
Pages (from-to)	R271-R274
Journal	Current Biology
Volume	20
Issue number	6
DOIs	https://doi.org/10.1016/j.cub.2010.01.048
State	Published - Mar 23 2010

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

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title = "Meiosis: A PRDM9 Guide to the Hotspots of Recombination",

abstract = "During meiosis, homologous recombination occurs preferentially at defined hotspots. In mammals, the fast-evolving DNA-binding domain of PRDM9 has now been identified as a major hotspot determinant that may explain the rapid rates of hotspot redistribution during evolution.",

author = "Andreas Hochwagen and Marais, {Gabriel A A.B.}",

year = "2010",

month = mar,

day = "23",

doi = "10.1016/j.cub.2010.01.048",

language = "English (US)",

volume = "20",

pages = "R271--R274",

journal = "Current Biology",

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TY - JOUR

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T2 - A PRDM9 Guide to the Hotspots of Recombination

AU - Hochwagen, Andreas

AU - Marais, Gabriel A A.B.

PY - 2010/3/23

Y1 - 2010/3/23

N2 - During meiosis, homologous recombination occurs preferentially at defined hotspots. In mammals, the fast-evolving DNA-binding domain of PRDM9 has now been identified as a major hotspot determinant that may explain the rapid rates of hotspot redistribution during evolution.

AB - During meiosis, homologous recombination occurs preferentially at defined hotspots. In mammals, the fast-evolving DNA-binding domain of PRDM9 has now been identified as a major hotspot determinant that may explain the rapid rates of hotspot redistribution during evolution.

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U2 - 10.1016/j.cub.2010.01.048

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M3 - Short survey

C2 - 20334833

AN - SCOPUS:77949630128

SN - 0960-9822

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SP - R271-R274

JO - Current Biology

JF - Current Biology

IS - 6

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Meiosis: A PRDM9 Guide to the Hotspots of Recombination

Abstract

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