Memory enhancement: Consolidation, reconsolidation and insulin-like growth factor 2

Cristina M. Alberini, Dillon Y. Chen

Research output: Contribution to journalReview article

Abstract

Life and societies would change significantly if memory capacity or persistence in health and disease could be enhanced. It has been known for many years that memory can be improved and strengthened. Substances known to enhance memory include hormones, neurotransmitters, neuropeptides and metabolic substrates. Recently, attention has been given to identifying the molecular mechanisms and targets whereby memory enhancement can be achieved. One approach would be to target the physiological changes that are induced by learning and naturally required for memory strengthening via consolidation and reconsolidation. Here, we review approaches that boost memories by targeting the cAMP response element binding protein-CCAAT enhancer binding protein (CREB-C/EBP) pathway and/or its recently identified target gene insulin-like growth factor 2 (IGF2).

Original languageEnglish (US)
Pages (from-to)274-283
Number of pages10
JournalTrends in Neurosciences
Volume35
Issue number5
DOIs
StatePublished - May 2012

Keywords

  • Cognitive enhancer
  • Growth factor
  • Memory consolidation
  • Reconsolidation

ASJC Scopus subject areas

  • Neuroscience(all)

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