Memory enhancement: Consolidation, reconsolidation and insulin-like growth factor 2

Cristina M. Alberini, Dillon Y. Chen

Research output: Contribution to journalReview articlepeer-review


Life and societies would change significantly if memory capacity or persistence in health and disease could be enhanced. It has been known for many years that memory can be improved and strengthened. Substances known to enhance memory include hormones, neurotransmitters, neuropeptides and metabolic substrates. Recently, attention has been given to identifying the molecular mechanisms and targets whereby memory enhancement can be achieved. One approach would be to target the physiological changes that are induced by learning and naturally required for memory strengthening via consolidation and reconsolidation. Here, we review approaches that boost memories by targeting the cAMP response element binding protein-CCAAT enhancer binding protein (CREB-C/EBP) pathway and/or its recently identified target gene insulin-like growth factor 2 (IGF2).

Original languageEnglish (US)
Pages (from-to)274-283
Number of pages10
JournalTrends in Neurosciences
Issue number5
StatePublished - May 2012


  • Cognitive enhancer
  • Growth factor
  • Memory consolidation
  • Reconsolidation

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Memory enhancement: Consolidation, reconsolidation and insulin-like growth factor 2'. Together they form a unique fingerprint.

Cite this