Mending the Heart Through In Situ Cardiac Regeneration

Jeremy Choon Meng Teo, Selwa Mokhtar Boularaoui, Noaf Salah Ali AlWahab, Nicolas Christoforou

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The mammalian heart has limited capacity for repair, and cardiomyocyte loss due to injury results in heart failure and death. Reports have suggested that cardiomyogenesis in the adult mammalian heart is still feasible through the manipulation of existing signaling pathways, which otherwise prevent cardiac regeneration from occurring. This has ignited an intense interest by groups attempting to understand the intrinsic cardiac regenerative capacity with a goal of manipulating it to activate a robust cardiac regeneration response, regain sufficient cardiac functional output, and ultimately improve the patient's life quality. Current strategies described here focus on (1) inducing cardiomyocytes to proliferate generating nascent functional contractile cells; (2) delivering cell progenitors with the capacity to differentiate into cardiomyocytes or vasculature; (3) activating intrinsic populations of cell progenitors or recruiting systemic cells to the myocardium; (4) genetically engineering the induction of regeneration in the existing myocardium; and (5) transdifferentiating cardiac nonmyocytes into cardiomyocytes.

Original languageEnglish (US)
Title of host publicationIn Situ Tissue Regeneration
Subtitle of host publicationHost Cell Recruitment and Biomaterial Design
PublisherElsevier Inc.
Pages313-344
Number of pages32
ISBN (Electronic)9780128025000
ISBN (Print)9780128022252
DOIs
StatePublished - Aug 5 2016

Keywords

  • Cardiac progenitor cells
  • Cardiac regeneration
  • Epigenetic reprogramming
  • Paracrine effect

ASJC Scopus subject areas

  • Medicine(all)

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