Metabolic modulation of potassium channels.

Dirk Trauner, Richard H. Kramer

Research output: Contribution to journalReview articlepeer-review


Recent investigations have shown that a range of small molecules that reflect the metabolic state of a cell regulate the activity of potassium channels. For instance, hydrogen peroxide has been shown to activate adenosine 5'-triphosphate-sensitive potassium channels (K(ATP) channels), whereas heme closes certain calcium-activated potassium channels. Although the exact function of the beta subunit associated with voltage-gated potassium channels is still unclear, its crystal structure suggests that membrane excitability is directly coupled to metabolism.

Original languageEnglish (US)
Pages (from-to)pe22
JournalScience's STKE : signal transduction knowledge environment
Issue number233
StatePublished - May 18 2004

ASJC Scopus subject areas

  • General Medicine


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