Metabolic network analysis integrated with transcript verification for sequenced genomes

Ani Manichaikul, Lila Ghamsari, Erik F.Y. Hom, Chenwei Lin, Ryan R. Murray, Roger L. Chang, S. Balaji, Tong Hao, Yun Shen, Arvind K. Chavali, Ines Thiele, Xinping Yang, Changyu Fan, Elizabeth Mello, David E. Hill, Marc Vidal, Kourosh Salehi-Ashtiani, Jason A. Papin

Research output: Contribution to journalArticlepeer-review


With sequencing of thousands of organisms completed or in progress, there is a growing need to integrate gene prediction with metabolic network analysis. Using Chlamydomonas reinhardtii as a model, we describe a systems-level methodology bridging metabolic network reconstruction with experimental verification of enzyme encoding open reading frames. Our quantitative and predictive metabolic model and its associated cloned open reading frames provide useful resources for metabolic engineering.

Original languageEnglish (US)
Pages (from-to)589-592
Number of pages4
JournalNature methods
Issue number8
StatePublished - 2009

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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