Metal ion-directed outside binding of small DNA ligand.

Toshihiro Ihara, Takashi Ikegami, Tomohiro Fujii, Yusuke Kitamura, Shinji Sueda, Makoto Takagi, Nicholas E. Geacintov, Akinori Jyo

Research output: Contribution to journalArticlepeer-review

Abstract

DNA binding of the ligand bearing an oxine and a pyridinium group was regulated by coexisting Cu2+ over the binding constant range of three orders of magnitude. The ligands coordinated to Cu2+ to form a dimer and then cooperatively bound outside of DNA duplex to give the well-regulated 1-D structure along the DNA backbone.

Original languageEnglish (US)
Pages (from-to)85-86
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number3
DOIs
StatePublished - 2003

ASJC Scopus subject areas

  • Medicine(all)

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