Metal-Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction

Simon Vecchioni; Brandon Lu; William Livernois; Yoel P. Ohayon; Jesse B. Yoder; Chu Fan Yang; Karol Woloszyn; William Bernfeld; M. P. Anantram; James W. Canary; Wayne A. Hendrickson; Lynn J. Rothschild; Chengde Mao; Shalom J. Wind; Nadrian C. Seeman; Ruojie Sha

doi:10.1002/adma.202210938

Metal-Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction

Simon Vecchioni, Brandon Lu, William Livernois, Yoel P. Ohayon, Jesse B. Yoder, Chu Fan Yang, Karol Woloszyn, William Bernfeld, M. P. Anantram, James W. Canary, Wayne A. Hendrickson, Lynn J. Rothschild, Chengde Mao, Shalom J. Wind, Nadrian C. Seeman, Ruojie Sha

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

DNA double helices containing metal-mediated DNA (mmDNA) base pairs are constructed from Ag⁺ and Hg²⁺ ions between pyrimidine:pyrimidine pairs with the promise of nanoelectronics. Rational design of mmDNA nanomaterials is impractical without a complete lexical and structural description. Here, the programmability of structural DNA nanotechnology toward its founding mission of self-assembling a diffraction platform for biomolecular structure determination is explored. The tensegrity triangle is employed to build a comprehensive structural library of mmDNA pairs via X-ray diffraction and generalized design rules for mmDNA construction are elucidated. Two binding modes are uncovered: N3-dominant, centrosymmetric pairs and major groove binders driven by 5-position ring modifications. Energy gap calculations show additional levels in the lowest unoccupied molecular orbitals (LUMO) of mmDNA structures, rendering them attractive molecular electronic candidates.

Original language	English (US)
Article number	2210938
Journal	Advanced Materials
Volume	35
Issue number	29
DOIs	https://doi.org/10.1002/adma.202210938
State	Published - Jul 20 2023

Keywords

DNA nanotechnology
X-ray diffraction
metal base pairs
molecular electronics
nanomaterials

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.202210938

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Vecchioni, S., Lu, B., Livernois, W., Ohayon, Y. P., Yoder, J. B., Yang, C. F., Woloszyn, K., Bernfeld, W., Anantram, M. P., Canary, J. W., Hendrickson, W. A., Rothschild, L. J., Mao, C., Wind, S. J., Seeman, N. C., & Sha, R. (2023). Metal-Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction. Advanced Materials, 35(29), Article 2210938. https://doi.org/10.1002/adma.202210938

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title = "Metal-Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction",

abstract = "DNA double helices containing metal-mediated DNA (mmDNA) base pairs are constructed from Ag+ and Hg2+ ions between pyrimidine:pyrimidine pairs with the promise of nanoelectronics. Rational design of mmDNA nanomaterials is impractical without a complete lexical and structural description. Here, the programmability of structural DNA nanotechnology toward its founding mission of self-assembling a diffraction platform for biomolecular structure determination is explored. The tensegrity triangle is employed to build a comprehensive structural library of mmDNA pairs via X-ray diffraction and generalized design rules for mmDNA construction are elucidated. Two binding modes are uncovered: N3-dominant, centrosymmetric pairs and major groove binders driven by 5-position ring modifications. Energy gap calculations show additional levels in the lowest unoccupied molecular orbitals (LUMO) of mmDNA structures, rendering them attractive molecular electronic candidates.",

keywords = "DNA nanotechnology, X-ray diffraction, metal base pairs, molecular electronics, nanomaterials",

author = "Simon Vecchioni and Brandon Lu and William Livernois and Ohayon, {Yoel P.} and Yoder, {Jesse B.} and Yang, {Chu Fan} and Karol Woloszyn and William Bernfeld and Anantram, {M. P.} and Canary, {James W.} and Hendrickson, {Wayne A.} and Rothschild, {Lynn J.} and Chengde Mao and Wind, {Shalom J.} and Seeman, {Nadrian C.} and Ruojie Sha",

note = "Publisher Copyright: {\textcopyright} 2023 Wiley-VCH GmbH.",

year = "2023",

month = jul,

day = "20",

doi = "10.1002/adma.202210938",

language = "English (US)",

volume = "35",

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T2 - Structural Library by Templated Diffraction

AU - Vecchioni, Simon

AU - Lu, Brandon

AU - Livernois, William

AU - Ohayon, Yoel P.

AU - Yoder, Jesse B.

AU - Yang, Chu Fan

AU - Woloszyn, Karol

AU - Bernfeld, William

AU - Anantram, M. P.

AU - Canary, James W.

AU - Hendrickson, Wayne A.

AU - Rothschild, Lynn J.

AU - Mao, Chengde

AU - Wind, Shalom J.

AU - Seeman, Nadrian C.

AU - Sha, Ruojie

PY - 2023/7/20

Y1 - 2023/7/20

N2 - DNA double helices containing metal-mediated DNA (mmDNA) base pairs are constructed from Ag+ and Hg2+ ions between pyrimidine:pyrimidine pairs with the promise of nanoelectronics. Rational design of mmDNA nanomaterials is impractical without a complete lexical and structural description. Here, the programmability of structural DNA nanotechnology toward its founding mission of self-assembling a diffraction platform for biomolecular structure determination is explored. The tensegrity triangle is employed to build a comprehensive structural library of mmDNA pairs via X-ray diffraction and generalized design rules for mmDNA construction are elucidated. Two binding modes are uncovered: N3-dominant, centrosymmetric pairs and major groove binders driven by 5-position ring modifications. Energy gap calculations show additional levels in the lowest unoccupied molecular orbitals (LUMO) of mmDNA structures, rendering them attractive molecular electronic candidates.

AB - DNA double helices containing metal-mediated DNA (mmDNA) base pairs are constructed from Ag+ and Hg2+ ions between pyrimidine:pyrimidine pairs with the promise of nanoelectronics. Rational design of mmDNA nanomaterials is impractical without a complete lexical and structural description. Here, the programmability of structural DNA nanotechnology toward its founding mission of self-assembling a diffraction platform for biomolecular structure determination is explored. The tensegrity triangle is employed to build a comprehensive structural library of mmDNA pairs via X-ray diffraction and generalized design rules for mmDNA construction are elucidated. Two binding modes are uncovered: N3-dominant, centrosymmetric pairs and major groove binders driven by 5-position ring modifications. Energy gap calculations show additional levels in the lowest unoccupied molecular orbitals (LUMO) of mmDNA structures, rendering them attractive molecular electronic candidates.

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KW - X-ray diffraction

KW - metal base pairs

KW - molecular electronics

KW - nanomaterials

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Metal-Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction

Abstract

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ASJC Scopus subject areas

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