Methodological challenges in treatment outcome research with ethnic minorities

Treatment outcome research focused on ethnic minorities is critically needed to eliminate mental health disparities. Because the conduct of treatment outcome research with ethnic minorities is difficult and complex, we discuss key challenges and present some methodological options suited to provide answers to specific types of questions. We focus first on the randomized clinical trial (RCT) paradigm, reviewing specific challenges facing investigators conducting ethnically inclusive trials. We then highlight the promise of other methods of inquiry to expand the science on mental health treatment with ethnic minorities.