Microbially-produced peptides having potential application to the prevention of dental caries

M. L. Chikindas, J. Novák, P. W. Caufield, K. Schilling, J. R. Tagg

Research output: Contribution to journalArticlepeer-review


Strategies advanced to decrease the occurrence of dental caries have in the past typically focussed upon attempting to reduce plaque accumulation by application of bread-spectrum antibacterial agents. In recent years however there has been growing interest in the application of a more targeted approach to the selective elimination from plaque of those bacterial species that are specifically implicated as the aetiological agents of this disease. This review focuses upon a number of the small bacterially-produced peptide antibiotics known as bacteriocins that are currently being explored for their potential role in the treatment and prevention of dental caries.

Original languageEnglish (US)
Pages (from-to)95-105
Number of pages11
JournalInternational Journal of Antimicrobial Agents
Issue number2
StatePublished - Sep 1997


  • Antibacterial peptides
  • Bacteriocin
  • Dental caries
  • Microbial interference

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)


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