Microbially-produced peptides having potential application to the prevention of dental caries

M. L. Chikindas; J. Novák; P. W. Caufield; K. Schilling; J. R. Tagg

doi:10.1016/S0924-8579(97)00040-X

Microbially-produced peptides having potential application to the prevention of dental caries

M. L. Chikindas, J. Novák, P. W. Caufield, K. Schilling, J. R. Tagg

Cariology and Comprehensive Care

Research output: Contribution to journal › Article › peer-review

Abstract

Strategies advanced to decrease the occurrence of dental caries have in the past typically focussed upon attempting to reduce plaque accumulation by application of bread-spectrum antibacterial agents. In recent years however there has been growing interest in the application of a more targeted approach to the selective elimination from plaque of those bacterial species that are specifically implicated as the aetiological agents of this disease. This review focuses upon a number of the small bacterially-produced peptide antibiotics known as bacteriocins that are currently being explored for their potential role in the treatment and prevention of dental caries.

Original language	English (US)
Pages (from-to)	95-105
Number of pages	11
Journal	International Journal of Antimicrobial Agents
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/S0924-8579(97)00040-X
State	Published - Sep 1997

Keywords

Antibacterial peptides
Bacteriocin
Dental caries
Microbial interference

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

Access to Document

10.1016/S0924-8579(97)00040-X

Cite this

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title = "Microbially-produced peptides having potential application to the prevention of dental caries",

abstract = "Strategies advanced to decrease the occurrence of dental caries have in the past typically focussed upon attempting to reduce plaque accumulation by application of bread-spectrum antibacterial agents. In recent years however there has been growing interest in the application of a more targeted approach to the selective elimination from plaque of those bacterial species that are specifically implicated as the aetiological agents of this disease. This review focuses upon a number of the small bacterially-produced peptide antibiotics known as bacteriocins that are currently being explored for their potential role in the treatment and prevention of dental caries.",

keywords = "Antibacterial peptides, Bacteriocin, Dental caries, Microbial interference",

author = "Chikindas, {M. L.} and J. Nov{\'a}k and Caufield, {P. W.} and K. Schilling and Tagg, {J. R.}",

note = "Funding Information: J.N. and P.W.C. were supported by grants from Unilever Dental Research,U K and the National Institute of Health (NIH grant ROl DE09082). J.T. is supportedb y grantsf rom the Health ResearchC ouncil of New Zealanda nd the New ZealandD ental Research Foundation.",

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AU - Chikindas, M. L.

AU - Novák, J.

AU - Caufield, P. W.

AU - Schilling, K.

AU - Tagg, J. R.

N1 - Funding Information: J.N. and P.W.C. were supported by grants from Unilever Dental Research,U K and the National Institute of Health (NIH grant ROl DE09082). J.T. is supportedb y grantsf rom the Health ResearchC ouncil of New Zealanda nd the New ZealandD ental Research Foundation.

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N2 - Strategies advanced to decrease the occurrence of dental caries have in the past typically focussed upon attempting to reduce plaque accumulation by application of bread-spectrum antibacterial agents. In recent years however there has been growing interest in the application of a more targeted approach to the selective elimination from plaque of those bacterial species that are specifically implicated as the aetiological agents of this disease. This review focuses upon a number of the small bacterially-produced peptide antibiotics known as bacteriocins that are currently being explored for their potential role in the treatment and prevention of dental caries.

AB - Strategies advanced to decrease the occurrence of dental caries have in the past typically focussed upon attempting to reduce plaque accumulation by application of bread-spectrum antibacterial agents. In recent years however there has been growing interest in the application of a more targeted approach to the selective elimination from plaque of those bacterial species that are specifically implicated as the aetiological agents of this disease. This review focuses upon a number of the small bacterially-produced peptide antibiotics known as bacteriocins that are currently being explored for their potential role in the treatment and prevention of dental caries.

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KW - Microbial interference

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Microbially-produced peptides having potential application to the prevention of dental caries

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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