@inproceedings{134273bfcf9a4dd4a38cff06dca6fd78,
title = "Microcavity single virus detection and sizing with molecular sensitivity",
abstract = "We report the label-free detection and sizing of the smallest individual RNA virus, MS2 by a spherical microcavity. Mass of this virus is ∼6 ag and produces a theoretical resonance shift ∼0.25 fm upon adsorbing an individual virus at the equator of the bare microcavity, which is well below the r.m.s background noise of 2 fm. However, detection was accomplished with ease (S/N = 8, Q = 4x105) using a single dipole stimulated plasmonic-nanoshell as a microcavity wavelength shift enhancer. Analytical expressions based on the {"}reactive sensing principle{"} are developed to extract the radius of the virus from the measured signals. Estimated limit of detection for these experiments was ∼0.4 ag or 240 kDa below the size of all known viruses, largest globular and elongated proteins [Phosphofructokinase (345 kDa) and Fibrinogen (390 kDa), respectively].",
keywords = "Whispering gallery mode, biosensor, localized surface plasmon resonance, microcavity, virus detection",
author = "Dantham, {V. R.} and S. Holler and V. Kolchenko and Z. Wan and S. Arnold",
year = "2013",
doi = "10.1117/12.2003098",
language = "English (US)",
isbn = "9780819493699",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
booktitle = "Laser Resonators, Microresonators, and Beam Control XV",
note = "Laser Resonators, Microresonators, and Beam Control XV ; Conference date: 03-02-2013 Through 07-02-2013",
}