@article{749d07806b8f43939615cddb2d118280,
title = "Microchemomechanical devices using DNA hybridization",
abstract = "The programmability of DNA oligonucleotides has led to sophisticated DNA nanotechnology and considerable research on DNA nanomachines powered by DNA hybridization. Here, we investigate an extension of this technology to the micrometer-colloidal scale, in which observations and measurements can be made in real time/space using optical microscopy and holographic optical tweezers. We use semirigid DNA origami structures, hinges with mechanical advantage, self-assembled into a nine-hinge, accordion-like chemomechanical device, with one end anchored to a substrate and a colloidal bead attached to the other end. Pulling the bead converts the mechanical energy into chemical energy stored by unzipping the DNA that bridges the hinge. Releasing the bead returns this energy in rapid (>20 μm/s) motion of the bead. Force-extension curves yield energy storage/retrieval in these devices that is very high. We also demonstrate remote activation and sensing—pulling the bead enables binding at a distant site. This work opens the door to easily designed and constructed micromechanical devices that bridge the molecular and colloidal/cellular scales.",
keywords = "Colloidal physics, DNA nanotechnology, Microchemomechanical devices, Self-assembly, Soft condensed matter",
author = "Guolong Zhu and Mark Hannel and Ruojie Sha and Feng Zhou and Zion, {Matan Yah Ben} and Yin Zhang and Kyle Bishop and David Grier and Nadrian Seeman and Paul Chaikin",
note = "Funding Information: We thank Prof. Alexander Grosberg for stimulating conversations; we also thank Dr. Mingxin He for discussion in particle synthesis. This research was primarily supported by the Center for Bio-Inspired Energy Sciences, an Energy Frontier Research Center funded by the US Department of Energy (DOE), Office of Sciences, Basic Energy Sciences, under Award No. DE-SC0000989 (G.Z., M.Y.B.Z., Y.Z., K.B., and P.C.) for conception, design, experiments, synthesis, and analysis. Partial support is by US DOE under Grant DE-SC0007991 (P.C., N.S., and R.S.) for initiation, management, and origami preparation and characterization and the Materials Research Science and Engineering Centers program of the NSF under Award No. DMR-1420073 (M.H. and D.G.) for laser tweezer construction and programming and for imaging analysis. Funding Information: ACKNOWLEDGMENTS. We thank Prof. Alexander Grosberg for stimulating conversations; we also thank Dr. Mingxin He for discussion in particle synthesis. This research was primarily supported by the Center for Bio- Publisher Copyright: {\textcopyright} 2021 National Academy of Sciences. All rights reserved.",
year = "2021",
month = may,
day = "25",
doi = "10.1073/pnas.2023508118",
language = "English (US)",
volume = "118",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "21",
}