Microfabricated nerve-electrode interfaces in neural prosthetics and neural engineering

Yong Ak Song, Ahmed M.S. Ibrahim, Amr N. Rabie, Jongyoon Han, Samuel J. Lin

Research output: Contribution to journalArticlepeer-review


Neural interfaces and implants are finding more clinical applications and there are rapid technological advances for more efficient and safe design, fabrication and materials to establish high-fidelity neural interfaces. In this review paper, we highlight new developments of the microfabricated electrodes and substrates with regard to the design, materials, fabrication and their clinical applications. There is a noticeable trend towards integration of microfluidic modules on a single neural platform. In addition to the microelectrodes for neural recording and stimulation, microfluidic channels are integrated into a nerve-electrode interface to explore the rich neurochemistry present at the neural interface and exploit it for enhanced electrochemical stimulation and recording of the central and peripheral nervous system.

Original languageEnglish (US)
Pages (from-to)113-134
Number of pages22
JournalBiotechnology and Genetic Engineering Reviews
Issue number2
StatePublished - Oct 1 2013


  • MEMS
  • Microelectrode array
  • Microfabrication
  • Neural engineering
  • Neural implant
  • Neural prosthetics

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Molecular Biology


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