Microfluidic device to interconnect multiple organs via fluidic circulation: Towards body-on-a-chip

Y. Kato; Y. Hirai; K. Kamei; T. Tsuchiya; O. Tabata

doi:10.1109/TRANSDUCERS.2015.7181233

Microfluidic device to interconnect multiple organs via fluidic circulation: Towards body-on-a-chip

Y. Kato, Y. Hirai, K. Kamei, T. Tsuchiya, O. Tabata

Biology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In vitro cell-based assay with human cells is getting attention as an alternative of conventional animal tests for more accurate drug screening and safety testing. We present a simplified microfluidic device (1) assembling multiple organs within a device and (2) integrating a closed-loop medium circulation system to investigate the effects of drugs/metabolites on various organs, namely body-on-a-chip. For its fabrication, a simple and reliable three-dimensional (3D) lithography with the process optimization method is applied to improve the current polydimethylsiloxane (PDMS) molding techniques. The fabricated double-layered PDMS microfluidic device is successfully applied to evaluate the effects of an anti-cancer drug (doxorubicin) on cell survival of two types of cells.

Original language	English (US)
Title of host publication	2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1549-1552
Number of pages	4
ISBN (Electronic)	9781479989553
DOIs	https://doi.org/10.1109/TRANSDUCERS.2015.7181233
State	Published - Aug 5 2015
Event	18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 - Anchorage, United States Duration: Jun 21 2015 → Jun 25 2015

Publication series

Name	2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015

Conference

Conference	18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
Country/Territory	United States
City	Anchorage
Period	6/21/15 → 6/25/15

Keywords

3D lithography
Body-on-a-chip
Cell-based assay
Microfluidic device
Pneumatic pump
Process optimization

ASJC Scopus subject areas

Instrumentation
Electrical and Electronic Engineering

Access to Document

10.1109/TRANSDUCERS.2015.7181233

Cite this

Kato, Y., Hirai, Y., Kamei, K., Tsuchiya, T., & Tabata, O. (2015). Microfluidic device to interconnect multiple organs via fluidic circulation: Towards body-on-a-chip. In 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 (pp. 1549-1552). Article 7181233 (2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/TRANSDUCERS.2015.7181233

Microfluidic device to interconnect multiple organs via fluidic circulation: Towards body-on-a-chip. / Kato, Y.; Hirai, Y.; Kamei, K. et al.
2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015. Institute of Electrical and Electronics Engineers Inc., 2015. p. 1549-1552 7181233 (2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Kato, Y, Hirai, Y, Kamei, K, Tsuchiya, T & Tabata, O 2015, Microfluidic device to interconnect multiple organs via fluidic circulation: Towards body-on-a-chip. in 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015., 7181233, 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015, Institute of Electrical and Electronics Engineers Inc., pp. 1549-1552, 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015, Anchorage, United States, 6/21/15. https://doi.org/10.1109/TRANSDUCERS.2015.7181233

Kato Y, Hirai Y, Kamei K, Tsuchiya T, Tabata O. Microfluidic device to interconnect multiple organs via fluidic circulation: Towards body-on-a-chip. In 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015. Institute of Electrical and Electronics Engineers Inc. 2015. p. 1549-1552. 7181233. (2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015). doi: 10.1109/TRANSDUCERS.2015.7181233

Kato, Y. ; Hirai, Y. ; Kamei, K. et al. / Microfluidic device to interconnect multiple organs via fluidic circulation : Towards body-on-a-chip. 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015. Institute of Electrical and Electronics Engineers Inc., 2015. pp. 1549-1552 (2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015).

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AB - In vitro cell-based assay with human cells is getting attention as an alternative of conventional animal tests for more accurate drug screening and safety testing. We present a simplified microfluidic device (1) assembling multiple organs within a device and (2) integrating a closed-loop medium circulation system to investigate the effects of drugs/metabolites on various organs, namely body-on-a-chip. For its fabrication, a simple and reliable three-dimensional (3D) lithography with the process optimization method is applied to improve the current polydimethylsiloxane (PDMS) molding techniques. The fabricated double-layered PDMS microfluidic device is successfully applied to evaluate the effects of an anti-cancer drug (doxorubicin) on cell survival of two types of cells.

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Microfluidic device to interconnect multiple organs via fluidic circulation: Towards body-on-a-chip

Abstract

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Conference

Keywords

ASJC Scopus subject areas

Access to Document

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