Microfluidic device to interconnect multiple organs via fluidic circulation: Towards body-on-a-chip

Y. Kato, Y. Hirai, K. Kamei, T. Tsuchiya, O. Tabata

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In vitro cell-based assay with human cells is getting attention as an alternative of conventional animal tests for more accurate drug screening and safety testing. We present a simplified microfluidic device (1) assembling multiple organs within a device and (2) integrating a closed-loop medium circulation system to investigate the effects of drugs/metabolites on various organs, namely body-on-a-chip. For its fabrication, a simple and reliable three-dimensional (3D) lithography with the process optimization method is applied to improve the current polydimethylsiloxane (PDMS) molding techniques. The fabricated double-layered PDMS microfluidic device is successfully applied to evaluate the effects of an anti-cancer drug (doxorubicin) on cell survival of two types of cells.

Original languageEnglish (US)
Title of host publication2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1549-1552
Number of pages4
ISBN (Electronic)9781479989553
DOIs
StatePublished - Aug 5 2015
Event18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 - Anchorage, United States
Duration: Jun 21 2015Jun 25 2015

Publication series

Name2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015

Conference

Conference18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
Country/TerritoryUnited States
CityAnchorage
Period6/21/156/25/15

Keywords

  • 3D lithography
  • Body-on-a-chip
  • Cell-based assay
  • Microfluidic device
  • Pneumatic pump
  • Process optimization

ASJC Scopus subject areas

  • Instrumentation
  • Electrical and Electronic Engineering

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