Microfluidic Electrokinetic Preconcentration Chips: Enhancing the detection of nucleic acids and exosomes

Jongmin Kim, Sarah Sahloul, Ajymurat Orozaliev, Vu Q. Do, Van Sang Pham, Diogo Martins, Xi Wei, Rastislav Levicky, Yong Ak Song

Research output: Contribution to journalArticlepeer-review

Abstract

Over the past few years, the detection of biological analytes has intensively been studied to understand the biodiagnostics of various diseases [1]. Some of the analytes that have been used as biomarkers for specific diseases include cell-free nucleic acids, (for example, DNA), messenger RNA (mRNA) and microRNA (miRNA) [2]-[5], circulating tumor-specific nucleic acids [circulating tumor DNA (ctDNA) and ctRNA] [6]-[8], exosomes [9], [10], and circulating tumor cells [11]. These biomolecules are known to be effective indicators that can diagnose the presence of a potential disease even if their concentration changes slightly [12].

Original languageEnglish (US)
Article number8986548
Pages (from-to)18-34
Number of pages17
JournalIEEE Nanotechnology Magazine
Volume14
Issue number2
DOIs
StatePublished - Apr 2020

ASJC Scopus subject areas

  • Mechanical Engineering
  • Electrical and Electronic Engineering

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