Microfluidic Electrokinetic Preconcentration Chips: Enhancing the detection of nucleic acids and exosomes

Jongmin Kim; Sarah Sahloul; Ajymurat Orozaliev; Vu Q. Do; Van Sang Pham; Diogo Martins; Xi Wei; Rastislav Levicky; Yong Ak Song

doi:10.1109/MNANO.2020.2966064

Microfluidic Electrokinetic Preconcentration Chips: Enhancing the detection of nucleic acids and exosomes

Jongmin Kim, Sarah Sahloul, Ajymurat Orozaliev, Vu Q. Do, Van Sang Pham, Diogo Martins, Xi Wei, Rastislav Levicky, Yong Ak Song

Research output: Contribution to journal › Article › peer-review

Abstract

Over the past few years, the detection of biological analytes has intensively been studied to understand the biodiagnostics of various diseases [1]. Some of the analytes that have been used as biomarkers for specific diseases include cell-free nucleic acids, (for example, DNA), messenger RNA (mRNA) and microRNA (miRNA) [2]-[5], circulating tumor-specific nucleic acids [circulating tumor DNA (ctDNA) and ctRNA] [6]-[8], exosomes [9], [10], and circulating tumor cells [11]. These biomolecules are known to be effective indicators that can diagnose the presence of a potential disease even if their concentration changes slightly [12].

Original language	English (US)
Article number	8986548
Pages (from-to)	18-34
Number of pages	17
Journal	IEEE Nanotechnology Magazine
Volume	14
Issue number	2
DOIs	https://doi.org/10.1109/MNANO.2020.2966064
State	Published - Apr 2020

ASJC Scopus subject areas

Mechanical Engineering
Electrical and Electronic Engineering

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Microfluidic Electrokinetic Preconcentration Chips : Enhancing the detection of nucleic acids and exosomes. / Kim, Jongmin; Sahloul, Sarah; Orozaliev, Ajymurat; Do, Vu Q.; Pham, Van Sang; Martins, Diogo; Wei, Xi; Levicky, Rastislav ; Song, Yong Ak.

In: IEEE Nanotechnology Magazine, Vol. 14, No. 2, 8986548, 04.2020, p. 18-34.

Research output: Contribution to journal › Article › peer-review

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