MicroRNA associated with dyslipidemia and coronary disease in humans

Elena Flowers; Bradley E. Aouizerat

doi:10.1152/physiolgenomics.00106.2013

MicroRNA associated with dyslipidemia and coronary disease in humans

Elena Flowers, Bradley E. Aouizerat

Oral and Maxillofacial Surgery

Research output: Contribution to journal › Review article › peer-review

Abstract

MicroRNAs are structural components of an epigenetic mechanism of posttranscriptional regulation of messenger RNA translation. Recently, there has been significant interest in the application of microRNA as a blood-based biomarker of underlying physiological conditions. Dyslipidemia is a complex, heterogeneous condition conferring substantially increased risk for cardiovascular disease. The purpose of this review is to describe the current body of knowledge on the role of microRNA regulation of lipoprotein metabolism in humans and to discuss relevant methodological and study design considerations. We highlight the potential roles for microRNA in geneenvironment interactions.

Original language	English (US)
Pages (from-to)	1199-1205
Number of pages	7
Journal	Physiological Genomics
Volume	45
Issue number	24
DOIs	https://doi.org/10.1152/physiolgenomics.00106.2013
State	Published - Dec 15 2013

Keywords

Lipids
MicroRNA

ASJC Scopus subject areas

Physiology
Genetics

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10.1152/physiolgenomics.00106.2013

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AB - MicroRNAs are structural components of an epigenetic mechanism of posttranscriptional regulation of messenger RNA translation. Recently, there has been significant interest in the application of microRNA as a blood-based biomarker of underlying physiological conditions. Dyslipidemia is a complex, heterogeneous condition conferring substantially increased risk for cardiovascular disease. The purpose of this review is to describe the current body of knowledge on the role of microRNA regulation of lipoprotein metabolism in humans and to discuss relevant methodological and study design considerations. We highlight the potential roles for microRNA in geneenvironment interactions.

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MicroRNA associated with dyslipidemia and coronary disease in humans

Abstract

Keywords

ASJC Scopus subject areas

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