MicroRNA regulation of lipid metabolism

Elena Flowers; Erika Sivarajan Froelicher; Bradley E. Aouizerat

doi:10.1016/j.metabol.2012.04.009

MicroRNA regulation of lipid metabolism

Elena Flowers, Erika Sivarajan Froelicher, Bradley E. Aouizerat

Oral and Maxillofacial Surgery

Research output: Contribution to journal › Review article › peer-review

Abstract

MicroRNAs are structural components of an epigenetic mechanism of post-transcriptional regulation of messenger RNA translation. Recently, there is significant interest in the application of microRNA as a blood-based biomarker of underlying physiologic conditions, and the therapeutic administration of microRNA inhibitors and mimics. The purpose of this review is to describe the current body of knowledge on microRNA regulation of genes involved in lipid metabolism, and to introduce the role of microRNA in development and progression of atherosclerosis.

Original language	English (US)
Pages (from-to)	12-20
Number of pages	9
Journal	Metabolism: Clinical and Experimental
Volume	62
Issue number	1
DOIs	https://doi.org/10.1016/j.metabol.2012.04.009
State	Published - Jan 2013

Keywords

Dyslipidemia
MicroRNA

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.metabol.2012.04.009

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title = "MicroRNA regulation of lipid metabolism",

abstract = "MicroRNAs are structural components of an epigenetic mechanism of post-transcriptional regulation of messenger RNA translation. Recently, there is significant interest in the application of microRNA as a blood-based biomarker of underlying physiologic conditions, and the therapeutic administration of microRNA inhibitors and mimics. The purpose of this review is to describe the current body of knowledge on microRNA regulation of genes involved in lipid metabolism, and to introduce the role of microRNA in development and progression of atherosclerosis.",

keywords = "Dyslipidemia, MicroRNA",

author = "Elena Flowers and Froelicher, {Erika Sivarajan} and Aouizerat, {Bradley E.}",

note = "Funding Information: Funding for Elena Flowers{\textquoteright} doctoral studies was provided by NIH/NIGMS R25 GM56847 , NIH/NCRR/OD UCSF-CTSI Grant TL1 RR024129 . Funding Information: Funding for Bradley E. Aouizerat was provided by NIH/NCRR/OD UCSF-CTSI Grant Number KL2 RR024130 . ",

year = "2013",

month = jan,

doi = "10.1016/j.metabol.2012.04.009",

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AU - Flowers, Elena

AU - Froelicher, Erika Sivarajan

AU - Aouizerat, Bradley E.

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PY - 2013/1

Y1 - 2013/1

N2 - MicroRNAs are structural components of an epigenetic mechanism of post-transcriptional regulation of messenger RNA translation. Recently, there is significant interest in the application of microRNA as a blood-based biomarker of underlying physiologic conditions, and the therapeutic administration of microRNA inhibitors and mimics. The purpose of this review is to describe the current body of knowledge on microRNA regulation of genes involved in lipid metabolism, and to introduce the role of microRNA in development and progression of atherosclerosis.

AB - MicroRNAs are structural components of an epigenetic mechanism of post-transcriptional regulation of messenger RNA translation. Recently, there is significant interest in the application of microRNA as a blood-based biomarker of underlying physiologic conditions, and the therapeutic administration of microRNA inhibitors and mimics. The purpose of this review is to describe the current body of knowledge on microRNA regulation of genes involved in lipid metabolism, and to introduce the role of microRNA in development and progression of atherosclerosis.

KW - Dyslipidemia

KW - MicroRNA

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M3 - Review article

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SN - 0026-0495

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SP - 12

EP - 20

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

IS - 1

ER -

MicroRNA regulation of lipid metabolism

Abstract

Keywords

ASJC Scopus subject areas

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