Abstract
The human 'P1' middle latency evoked potential is postulated to be generated in the thalamus by a cholinergic component of the ascending reticular activating system. To test the hypothesis that P1 and its generator substrate are abnormal in Alzheimer's disease (AD), a disorder of marked cholinergic deficiency, recordings of middle latency responses to click stimuli were carried out. Comparisons between the AD and age-matched control groups indicated normal auditory brain-stem and Pa responses but a significant decrease in P1 amplitude. This P1 abnormality suggests that the midbrain cholinergic cells in AD may be dysfunctional.
Original language | English (US) |
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Pages (from-to) | 378-384 |
Number of pages | 7 |
Journal | Electroencephalography and Clinical Neurophysiology/ Evoked Potentials |
Volume | 74 |
Issue number | 5 |
DOIs | |
State | Published - 1989 |
Keywords
- Alzheimer's disease
- Ascending reticular system
- Cholinergic brain-stem system
- Midlatency auditory evoked responses
- P1 abnormality
ASJC Scopus subject areas
- General Neuroscience
- Clinical Neurology