Midlatency auditory evoked responses: differential abnormality of P1 in Alzheimer's disease

J. S. Buchwald, R. J. Erwin, S. Read, D. Van Lancker, J. L. Cummings

Research output: Contribution to journalArticlepeer-review


The human 'P1' middle latency evoked potential is postulated to be generated in the thalamus by a cholinergic component of the ascending reticular activating system. To test the hypothesis that P1 and its generator substrate are abnormal in Alzheimer's disease (AD), a disorder of marked cholinergic deficiency, recordings of middle latency responses to click stimuli were carried out. Comparisons between the AD and age-matched control groups indicated normal auditory brain-stem and Pa responses but a significant decrease in P1 amplitude. This P1 abnormality suggests that the midbrain cholinergic cells in AD may be dysfunctional.

Original languageEnglish (US)
Pages (from-to)378-384
Number of pages7
JournalElectroencephalography and Clinical Neurophysiology/ Evoked Potentials
Issue number5
StatePublished - 1989


  • Alzheimer's disease
  • Ascending reticular system
  • Cholinergic brain-stem system
  • Midlatency auditory evoked responses
  • P1 abnormality

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology


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