Mighty Piwis Defend the Germline against Genome Intruders

Kathryn A. O'Donnell, Jef D. Boeke

    Research output: Contribution to journalReview article

    Abstract

    Piwis are a germline-specific subclass of the Argonaute family of RNA interference (RNAi) effector proteins that are associated with a recently discovered group of small RNAs (piRNAs). Recent studies in Drosophila and zebrafish directly implicate Piwi proteins in piRNA biogenesis to maintain transposon silencing in the germline genome (Brennecke et al., 2007; Gunawardane et al., 2007; Houwing et al., 2007). This function may be conserved in mice as loss of Miwi2, a mouse Piwi homolog, leads to germline stem cell and meiotic defects correlated with increased transposon activity (Carmell et al., 2007).

    Original languageEnglish (US)
    Pages (from-to)37-44
    Number of pages8
    JournalCell
    Volume129
    Issue number1
    DOIs
    StatePublished - Apr 6 2007

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

    Fingerprint Dive into the research topics of 'Mighty Piwis Defend the Germline against Genome Intruders'. Together they form a unique fingerprint.

  • Cite this