Mighty Piwis Defend the Germline against Genome Intruders

Kathryn A. O'Donnell, Jef D. Boeke

Research output: Contribution to journalReview articlepeer-review


Piwis are a germline-specific subclass of the Argonaute family of RNA interference (RNAi) effector proteins that are associated with a recently discovered group of small RNAs (piRNAs). Recent studies in Drosophila and zebrafish directly implicate Piwi proteins in piRNA biogenesis to maintain transposon silencing in the germline genome (Brennecke et al., 2007; Gunawardane et al., 2007; Houwing et al., 2007). This function may be conserved in mice as loss of Miwi2, a mouse Piwi homolog, leads to germline stem cell and meiotic defects correlated with increased transposon activity (Carmell et al., 2007).

Original languageEnglish (US)
Pages (from-to)37-44
Number of pages8
Issue number1
StatePublished - Apr 6 2007

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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