Migratory flyway and geographical distance are barriers to the gene flow of influenza virus among North American birds

Tommy Tsan Yuk Lam, Hon S. Ip, Elodie Ghedin, David E. Wentworth, Rebecca A. Halpin, Timothy B. Stockwell, David J. Spiro, Robert J. Dusek, James B. Bortner, Jenny Hoskins, Bradley D. Bales, Dan R. Yparraguirre, Edward C. Holmes

Research output: Contribution to journalArticle

Abstract

Despite the importance of migratory birds in the ecology and evolution of avian influenza virus (AIV), there is a lack of information on the patterns of AIV spread at the intra-continental scale. We applied a variety of statistical phylogeographic techniques to a plethora of viral genome sequence data to determine the strength, pattern and determinants of gene flow in AIV sampled from wild birds in North America. These analyses revealed a clear isolation-by-distance of AIV among sampling localities. In addition, we show that phylogeographic models incorporating information on the avian flyway of sampling proved a better fit to the observed sequence data than those specifying homogeneous or random rates of gene flow among localities. In sum, these data strongly suggest that the intra-continental spread of AIV by migratory birds is subject to major ecological barriers, including spatial distance and avian flyway.

Original languageEnglish (US)
Pages (from-to)24-33
Number of pages10
JournalEcology Letters
Volume15
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • Avian influenza
  • Ecological barriers
  • Evolution
  • Flyways
  • Gene flow
  • Phylogeography
  • Spatial distance

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics

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  • Cite this

    Lam, T. T. Y., Ip, H. S., Ghedin, E., Wentworth, D. E., Halpin, R. A., Stockwell, T. B., Spiro, D. J., Dusek, R. J., Bortner, J. B., Hoskins, J., Bales, B. D., Yparraguirre, D. R., & Holmes, E. C. (2012). Migratory flyway and geographical distance are barriers to the gene flow of influenza virus among North American birds. Ecology Letters, 15(1), 24-33. https://doi.org/10.1111/j.1461-0248.2011.01703.x