Mimicry of a β-Hairpin Turn by a Nonpeptidic Laterally Flexible Foldamer

Joseph W. Meisel, Chunhua T. Hu, Andrew D. Hamilton

Research output: Contribution to journalArticle

Abstract

The design and characterization of a proteomimetic foldamer that displays lateral flexibility endowed by intramolecular bifurcated hydrogen bonds is reported. The MAMBA scaffold, derived from meta-aminomethylbenzoic acid, adopts a serpentine conformation that mimics the side chain projection of all four residues in a β-hairpin turn.

Original languageEnglish (US)
Pages (from-to)3879-3882
Number of pages4
JournalOrganic Letters
Volume20
Issue number13
DOIs
StatePublished - Jul 6 2018

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Mimicry of a β-Hairpin Turn by a Nonpeptidic Laterally Flexible Foldamer'. Together they form a unique fingerprint.

  • Cite this