Mini-review: Can non-human leucocyte antigen genes determine susceptibility to severe dengue syndromes?

Dorothy Ng; Aparna Ghosh; Mark Jit; Suranjith L. Seneviratne

doi:10.1093/trstmh/trx075

Mini-review: Can non-human leucocyte antigen genes determine susceptibility to severe dengue syndromes?

Dorothy Ng, Aparna Ghosh, Mark Jit, Suranjith L. Seneviratne

Global Public Health

Research output: Contribution to journal › Review article › peer-review

Abstract

Dengue viral infections are endemic or epidemic in virtually all tropical countries. Among individuals infected with the dengue virus, severe dengue syndromes (i.e., dengue haemorrhagic fever and dengue shock syndromes) tend to affect only some and this may be due to a combination of host genetic susceptibility and viral factors. In this review article we analyse and discuss the present knowledge of non-human leucocyte antigen host genetic susceptibility to severe dengue syndromes. The relevance of genetic polymorphisms in the pathways of antigen recognition, uptake, processing and presentation, activation of interferon α responses, mast cell and complement activation and T cell activation and dengue disease severity has been reviewed and analysed.

Original language	English (US)
Pages (from-to)	384-392
Number of pages	9
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	111
Issue number	9
DOIs	https://doi.org/10.1093/trstmh/trx075
State	Published - Sep 1 2017

Keywords

Dengue
Genetic
Humans
Polymorphism

ASJC Scopus subject areas

Parasitology
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1093/trstmh/trx075

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abstract = "Dengue viral infections are endemic or epidemic in virtually all tropical countries. Among individuals infected with the dengue virus, severe dengue syndromes (i.e., dengue haemorrhagic fever and dengue shock syndromes) tend to affect only some and this may be due to a combination of host genetic susceptibility and viral factors. In this review article we analyse and discuss the present knowledge of non-human leucocyte antigen host genetic susceptibility to severe dengue syndromes. The relevance of genetic polymorphisms in the pathways of antigen recognition, uptake, processing and presentation, activation of interferon α responses, mast cell and complement activation and T cell activation and dengue disease severity has been reviewed and analysed.",

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AU - Ng, Dorothy

AU - Ghosh, Aparna

AU - Jit, Mark

AU - Seneviratne, Suranjith L.

N1 - Publisher Copyright: © The Author(s) 2018.

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N2 - Dengue viral infections are endemic or epidemic in virtually all tropical countries. Among individuals infected with the dengue virus, severe dengue syndromes (i.e., dengue haemorrhagic fever and dengue shock syndromes) tend to affect only some and this may be due to a combination of host genetic susceptibility and viral factors. In this review article we analyse and discuss the present knowledge of non-human leucocyte antigen host genetic susceptibility to severe dengue syndromes. The relevance of genetic polymorphisms in the pathways of antigen recognition, uptake, processing and presentation, activation of interferon α responses, mast cell and complement activation and T cell activation and dengue disease severity has been reviewed and analysed.

AB - Dengue viral infections are endemic or epidemic in virtually all tropical countries. Among individuals infected with the dengue virus, severe dengue syndromes (i.e., dengue haemorrhagic fever and dengue shock syndromes) tend to affect only some and this may be due to a combination of host genetic susceptibility and viral factors. In this review article we analyse and discuss the present knowledge of non-human leucocyte antigen host genetic susceptibility to severe dengue syndromes. The relevance of genetic polymorphisms in the pathways of antigen recognition, uptake, processing and presentation, activation of interferon α responses, mast cell and complement activation and T cell activation and dengue disease severity has been reviewed and analysed.

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KW - Humans

KW - Polymorphism

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Mini-review: Can non-human leucocyte antigen genes determine susceptibility to severe dengue syndromes?

Abstract

Keywords

ASJC Scopus subject areas

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