Mining the jewels of the cortex's crowning mystery

Leena A. Ibrahim, Ben Schuman, Rachel Bandler, Bernardo Rudy, Gord Fishell

Research output: Contribution to journalReview articlepeer-review


Neocortical Layer 1 consists of a dense mesh of excitatory and inhibitory axons, dendrites of pyramidal neurons, as well as neuromodulatory inputs from diverse brain regions. Layer 1 also consists of a sparse population of inhibitory interneurons, which are appropriately positioned to receive and integrate the information from these regions of the brain and modulate cortical processing. Despite being among the sparsest neuronal population in the cortex, Layer 1 interneurons perform powerful computations and have elaborate morphologies. Here we review recent studies characterizing their origin, morphology, physiology, and molecular profiles, as well as their connectivity and in vivo response properties.

Original languageEnglish (US)
Pages (from-to)154-161
Number of pages8
JournalCurrent Opinion in Neurobiology
StatePublished - Aug 2020

ASJC Scopus subject areas

  • General Neuroscience


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