MiR-30b/30d Regulation of GalNAc Transferases Enhances Invasion and Immunosuppression during Metastasis

Avital Gaziel-Sovran, Miguel F. Segura, Raffaella Di Micco, Mary K. Collins, Douglas Hanniford, Eleazar Vega-Saenz de Miera, John F. Rakus, John F. Dankert, Shulian Shang, Robert S. Kerbel, Nina Bhardwaj, Yongzhao Shao, Farbod Darvishian, Jiri Zavadil, Adrian Erlebacher, Lara K. Mahal, Iman Osman, Eva Hernando

Research output: Contribution to journalArticlepeer-review


To metastasize, a tumor cell must acquire abilities such as the capacity to colonize new tissue and evade immune surveillance. Recent evidence suggests that microRNAs can promote the evolution of malignant behaviors by regulating multiple targets. We performed a microRNA analysis of human melanoma, a highly invasive cancer, and found that miR-30b/30d upregulation correlates with stage, metastatic potential, shorter time to recurrence, and reduced overall survival. Ectopic expression of miR-30b/30d promoted the metastatic behavior of melanoma cells by directly targeting the GalNAc transferase GALNT7, resulted in increased synthesis of the immunosuppressive cytokine IL-10, and reduced immune cell activation and recruitment. These data support a key role of miR-30b/30d and GalNAc transferases in metastasis, by simultaneously promoting cellular invasion and immunosuppression.

Original languageEnglish (US)
Pages (from-to)104-118
Number of pages15
JournalCancer Cell
Issue number1
StatePublished - Jul 12 2011

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'MiR-30b/30d Regulation of GalNAc Transferases Enhances Invasion and Immunosuppression during Metastasis'. Together they form a unique fingerprint.

Cite this