Mitigation of electronic crosstalk interference in graphene transistor biosensors

The need for higher sensitivity and parallel detection of multiple biological targets drives the research on electronic biosensing platforms based on two-dimensional (2D) materials. However, signal fidelity from individual sensors may be compromised due to the existing nonidealities of 2D electronic devices. Here, we use graphene field effect transistors (gFETs) as a model system to investigate a multisensor device architecture. We identify two potential sources of crosstalk interference between sensors in such a platform: resistive interference through shared gFET channels and capacitive coupling through the shared device substrate. Having illustrated these sources of interference, we offer solutions to mitigate them for ensuring the fidelity of the biosensor signal. This study provides important practical insights for researchers working on 2D biosensor platforms.