Mitochondrial ion channels as therapeutic targets

Pablo M. Peixoto; Shin Young Ryu; Kathleen W. Kinnally

doi:10.1016/j.febslet.2010.02.046

Mitochondrial ion channels as therapeutic targets

Pablo M. Peixoto, Shin Young Ryu, Kathleen W. Kinnally

Research output: Contribution to journal › Review article › peer-review

Abstract

The study of mitochondrial ion channels changed our perception of these double-wrapped organelles from being just the power house of a cell to the guardian of a cell's fate. Mitochondria communicate with the cell through these special channels. Most of the time, the message is encoded by ion flow across the mitochondrial outer and inner membranes. Potassium, sodium, calcium, protons, nucleotides, and proteins traverse the mitochondrial membranes in an exquisitely regulated manner to control a myriad of processes, from respiration and mitochondrial morphology to cell proliferation and cell death. This review is an update on both well established and putative mitochondrial channels regarding their composition, function, regulation, and therapeutic potential.

Original language	English (US)
Pages (from-to)	2142-2152
Number of pages	11
Journal	FEBS Letters
Volume	584
Issue number	10
DOIs	https://doi.org/10.1016/j.febslet.2010.02.046
State	Published - May 2010

Keywords

Mitochondrial disease
Mitochondrial ion channels
Patch clamp
Therapy

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

Access to Document

10.1016/j.febslet.2010.02.046

Cite this

@article{0c9c117ef5234a5f9daafa2242e13567,

title = "Mitochondrial ion channels as therapeutic targets",

abstract = "The study of mitochondrial ion channels changed our perception of these double-wrapped organelles from being just the power house of a cell to the guardian of a cell's fate. Mitochondria communicate with the cell through these special channels. Most of the time, the message is encoded by ion flow across the mitochondrial outer and inner membranes. Potassium, sodium, calcium, protons, nucleotides, and proteins traverse the mitochondrial membranes in an exquisitely regulated manner to control a myriad of processes, from respiration and mitochondrial morphology to cell proliferation and cell death. This review is an update on both well established and putative mitochondrial channels regarding their composition, function, regulation, and therapeutic potential.",

keywords = "Mitochondrial disease, Mitochondrial ion channels, Patch clamp, Therapy",

author = "Peixoto, {Pablo M.} and Ryu, {Shin Young} and Kinnally, {Kathleen W.}",

note = "Funding Information: This work was supported by the National Institutes of Health [Grant GM57249 ] to K.W.K. many important papers were not cited here, because of space constrains. They can be found in the excellent reviews we referred to.",

year = "2010",

month = may,

doi = "10.1016/j.febslet.2010.02.046",

language = "English (US)",

volume = "584",

pages = "2142--2152",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "John Wiley and Sons Inc.",

number = "10",

}

TY - JOUR

T1 - Mitochondrial ion channels as therapeutic targets

AU - Peixoto, Pablo M.

AU - Ryu, Shin Young

AU - Kinnally, Kathleen W.

N1 - Funding Information: This work was supported by the National Institutes of Health [Grant GM57249 ] to K.W.K. many important papers were not cited here, because of space constrains. They can be found in the excellent reviews we referred to.

PY - 2010/5

Y1 - 2010/5

N2 - The study of mitochondrial ion channels changed our perception of these double-wrapped organelles from being just the power house of a cell to the guardian of a cell's fate. Mitochondria communicate with the cell through these special channels. Most of the time, the message is encoded by ion flow across the mitochondrial outer and inner membranes. Potassium, sodium, calcium, protons, nucleotides, and proteins traverse the mitochondrial membranes in an exquisitely regulated manner to control a myriad of processes, from respiration and mitochondrial morphology to cell proliferation and cell death. This review is an update on both well established and putative mitochondrial channels regarding their composition, function, regulation, and therapeutic potential.

AB - The study of mitochondrial ion channels changed our perception of these double-wrapped organelles from being just the power house of a cell to the guardian of a cell's fate. Mitochondria communicate with the cell through these special channels. Most of the time, the message is encoded by ion flow across the mitochondrial outer and inner membranes. Potassium, sodium, calcium, protons, nucleotides, and proteins traverse the mitochondrial membranes in an exquisitely regulated manner to control a myriad of processes, from respiration and mitochondrial morphology to cell proliferation and cell death. This review is an update on both well established and putative mitochondrial channels regarding their composition, function, regulation, and therapeutic potential.

KW - Mitochondrial disease

KW - Mitochondrial ion channels

KW - Patch clamp

KW - Therapy

UR - http://www.scopus.com/inward/record.url?scp=77952670367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952670367&partnerID=8YFLogxK

U2 - 10.1016/j.febslet.2010.02.046

DO - 10.1016/j.febslet.2010.02.046

M3 - Review article

C2 - 20178788

AN - SCOPUS:77952670367

SN - 0014-5793

VL - 584

SP - 2142

EP - 2152

JO - FEBS Letters

JF - FEBS Letters

IS - 10

ER -

Mitochondrial ion channels as therapeutic targets

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this