Mitochondrial ion channels as therapeutic targets

Pablo M. Peixoto, Shin Young Ryu, Kathleen W. Kinnally

Research output: Contribution to journalReview article

Abstract

The study of mitochondrial ion channels changed our perception of these double-wrapped organelles from being just the power house of a cell to the guardian of a cell's fate. Mitochondria communicate with the cell through these special channels. Most of the time, the message is encoded by ion flow across the mitochondrial outer and inner membranes. Potassium, sodium, calcium, protons, nucleotides, and proteins traverse the mitochondrial membranes in an exquisitely regulated manner to control a myriad of processes, from respiration and mitochondrial morphology to cell proliferation and cell death. This review is an update on both well established and putative mitochondrial channels regarding their composition, function, regulation, and therapeutic potential.

Original languageEnglish (US)
Pages (from-to)2142-2152
Number of pages11
JournalFEBS Letters
Volume584
Issue number10
DOIs
StatePublished - May 2010

Keywords

  • Mitochondrial disease
  • Mitochondrial ion channels
  • Patch clamp
  • Therapy

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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  • Cite this

    Peixoto, P. M., Ryu, S. Y., & Kinnally, K. W. (2010). Mitochondrial ion channels as therapeutic targets. FEBS Letters, 584(10), 2142-2152. https://doi.org/10.1016/j.febslet.2010.02.046