Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels

Shin Young Ryu, Gisela Beutner, Robert T. Dirksen, Kathleen W. Kinnally, Shey Shing Sheu

Research output: Contribution to journalReview articlepeer-review


Ca2+ channels that underlie mitochondrial Ca2+ transport first reported decades ago have now just recently been precisely characterized electrophysiologically. Numerous data indicate that mitochondrial Ca2+ uptake via these channels regulates multiple intracellular processes by shaping cytosolic and mitochondrial Ca2+ transients, as well as altering the cellular metabolic and redox state. On the other hand, mitochondrial Ca2+ overload also initiates a cascade of events that leads to cell death. Thus, characterization of mitochondrial Ca2+ channels is central to a comprehensive understanding of cell signaling. Here, we discuss recent progresses in the biophysical and electrophysiological characterization of several distinct mitochondrial Ca2+ channels.

Original languageEnglish (US)
Pages (from-to)1948-1955
Number of pages8
JournalFEBS Letters
Issue number10
StatePublished - May 2010


  • Ca channel
  • Mitochondrial Ca uniporter (MCU)
  • Mitochondrial ryanodine receptor (mRyR)
  • Rapid mode Ca uptake (RaM)
  • Ru360
  • Ruthenium red
  • Ryanodine

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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