Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels

Shin Young Ryu, Gisela Beutner, Robert T. Dirksen, Kathleen W. Kinnally, Shey Shing Sheu

    Research output: Contribution to journalReview articlepeer-review


    Ca2+ channels that underlie mitochondrial Ca2+ transport first reported decades ago have now just recently been precisely characterized electrophysiologically. Numerous data indicate that mitochondrial Ca2+ uptake via these channels regulates multiple intracellular processes by shaping cytosolic and mitochondrial Ca2+ transients, as well as altering the cellular metabolic and redox state. On the other hand, mitochondrial Ca2+ overload also initiates a cascade of events that leads to cell death. Thus, characterization of mitochondrial Ca2+ channels is central to a comprehensive understanding of cell signaling. Here, we discuss recent progresses in the biophysical and electrophysiological characterization of several distinct mitochondrial Ca2+ channels.

    Original languageEnglish (US)
    Pages (from-to)1948-1955
    Number of pages8
    JournalFEBS Letters
    Issue number10
    StatePublished - May 2010


    • Ca channel
    • Mitochondrial Ca uniporter (MCU)
    • Mitochondrial ryanodine receptor (mRyR)
    • Rapid mode Ca uptake (RaM)
    • Ru360
    • Ruthenium red
    • Ryanodine

    ASJC Scopus subject areas

    • Biophysics
    • Structural Biology
    • Biochemistry
    • Molecular Biology
    • Genetics
    • Cell Biology


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