Mitosis and DNA Synthesis in Mouse Kidney: Sources of Error in Evaluating Cell Proliferation

Daniel Malamud, Jean Paddock, Ronald A. Malt

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Approximately 48 hr after removal of one mouse kidney, the specific activity of DNA increased about 2-fold and was confirmed by autoradiographic studies and mitotic counts. A similar increase in DNA specific activity was produced by touching a normal kidney with forceps imperceptibly wet with isopropanol-hexachlorophene, but autoradiography showed proliferative activity confined to the subcapsular region rather than throughout the proximal tubules.

    Original languageEnglish (US)
    Pages (from-to)28-31
    Number of pages4
    JournalProceedings of the Society for Experimental Biology and Medicine
    Volume139
    Issue number1
    DOIs
    StatePublished - Jan 1972

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

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