TY - GEN
T1 - Mixed-effects shape models for estimating longitudinal changes in anatomy
AU - Datar, Manasi
AU - Muralidharan, Prasanna
AU - Kumar, Abhishek
AU - Gouttard, Sylvain
AU - Piven, Joseph
AU - Gerig, Guido
AU - Whitaker, Ross
AU - Fletcher, P. Thomas
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012
Y1 - 2012
N2 - In this paper, we propose a new method for longitudinal shape analysis that fits a linear mixed-effects model, while simultaneously optimizing correspondences on a set of anatomical shapes. Shape changes are modeled in a hierarchical fashion, with the global population trend as a fixed effect and individual trends as random effects. The statistical significance of the estimated trends are evaluated using specifically designed permutation tests. We also develop a permutation test based on the Hotelling T 2 statistic to compare the average shapes trends between two populations. We demonstrate the benefits of our method on a synthetic example of longitudinal tori and data from a developmental neuroimaging study.
AB - In this paper, we propose a new method for longitudinal shape analysis that fits a linear mixed-effects model, while simultaneously optimizing correspondences on a set of anatomical shapes. Shape changes are modeled in a hierarchical fashion, with the global population trend as a fixed effect and individual trends as random effects. The statistical significance of the estimated trends are evaluated using specifically designed permutation tests. We also develop a permutation test based on the Hotelling T 2 statistic to compare the average shapes trends between two populations. We demonstrate the benefits of our method on a synthetic example of longitudinal tori and data from a developmental neuroimaging study.
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U2 - 10.1007/978-3-642-33555-6_7
DO - 10.1007/978-3-642-33555-6_7
M3 - Conference contribution
AN - SCOPUS:84867854554
SN - 9783642335549
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 76
EP - 87
BT - Spatio-temporal Image Analysis for Longitudinal and Time-Series Image Data - Second International Workshop, STIA 2012, Held in Conjunction with MICCAI 2012, Proceedings
T2 - 2nd International Workshop on Spatiotemporal Image Analysis for Longitudinal and Time-Series Image Data, STIA 2012, Held in Conjunction with the International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2012
Y2 - 1 October 2012 through 1 October 2012
ER -