Model based conjectures on mammalian clock controversies

Daniel B. Forger; Charles S. Peskin

doi:10.1016/j.jtbi.2004.04.041

Model based conjectures on mammalian clock controversies

Daniel B. Forger, Charles S. Peskin

Mathematics

Research output: Contribution to journal › Article › peer-review

Abstract

We explore some predictions of a previously developed detailed model of molecular timekeeping in mammals (Forger and Peskin, PNAS, 100:14806) in areas where our understanding of clock mechanisms are incomplete. It is conjectured that: (1) the clock's 24-h period depends on mRNA stability. (2) REV-ERBα suppresses and/or entrains rhythms in peripheral tissues by regulating CRY1 transcription. (3) CLK:BMAL1 oscillations are suppressed in the suprachiasmatic nuclei to enhance oscillations in other proteins. (4) PER2 is ineffective at causing phase advances because it is not induced by light during the late night. (5) The clock is a limit cycle oscillator that shows characteristics of the Evening and Morning oscillator model.

Original language	English (US)
Pages (from-to)	533-539
Number of pages	7
Journal	Journal of Theoretical Biology
Volume	230
Issue number	4 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.jtbi.2004.04.041
State	Published - Oct 21 2004

Keywords

BMAL Rev-erbα
CLOCK
CRY
Circadian Clock
Eukaryotic transcription regulation
Mathematical models
PER
Phase response curve

ASJC Scopus subject areas

Statistics and Probability
Modeling and Simulation
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Agricultural and Biological Sciences
Applied Mathematics

Access to Document

10.1016/j.jtbi.2004.04.041

Cite this

@article{d1c3ba544d484089a90345173707ab81,

title = "Model based conjectures on mammalian clock controversies",

abstract = "We explore some predictions of a previously developed detailed model of molecular timekeeping in mammals (Forger and Peskin, PNAS, 100:14806) in areas where our understanding of clock mechanisms are incomplete. It is conjectured that: (1) the clock's 24-h period depends on mRNA stability. (2) REV-ERBα suppresses and/or entrains rhythms in peripheral tissues by regulating CRY1 transcription. (3) CLK:BMAL1 oscillations are suppressed in the suprachiasmatic nuclei to enhance oscillations in other proteins. (4) PER2 is ineffective at causing phase advances because it is not induced by light during the late night. (5) The clock is a limit cycle oscillator that shows characteristics of the Evening and Morning oscillator model.",

keywords = "BMAL Rev-erbα, CLOCK, CRY, Circadian Clock, Eukaryotic transcription regulation, Mathematical models, PER, Phase response curve",

author = "Forger, {Daniel B.} and Peskin, {Charles S.}",

year = "2004",

month = oct,

day = "21",

doi = "10.1016/j.jtbi.2004.04.041",

language = "English (US)",

volume = "230",

pages = "533--539",

journal = "Journal of Theoretical Biology",

issn = "0022-5193",

publisher = "Academic Press",

number = "4 SPEC. ISS.",

}

TY - JOUR

T1 - Model based conjectures on mammalian clock controversies

AU - Forger, Daniel B.

AU - Peskin, Charles S.

PY - 2004/10/21

Y1 - 2004/10/21

N2 - We explore some predictions of a previously developed detailed model of molecular timekeeping in mammals (Forger and Peskin, PNAS, 100:14806) in areas where our understanding of clock mechanisms are incomplete. It is conjectured that: (1) the clock's 24-h period depends on mRNA stability. (2) REV-ERBα suppresses and/or entrains rhythms in peripheral tissues by regulating CRY1 transcription. (3) CLK:BMAL1 oscillations are suppressed in the suprachiasmatic nuclei to enhance oscillations in other proteins. (4) PER2 is ineffective at causing phase advances because it is not induced by light during the late night. (5) The clock is a limit cycle oscillator that shows characteristics of the Evening and Morning oscillator model.

AB - We explore some predictions of a previously developed detailed model of molecular timekeeping in mammals (Forger and Peskin, PNAS, 100:14806) in areas where our understanding of clock mechanisms are incomplete. It is conjectured that: (1) the clock's 24-h period depends on mRNA stability. (2) REV-ERBα suppresses and/or entrains rhythms in peripheral tissues by regulating CRY1 transcription. (3) CLK:BMAL1 oscillations are suppressed in the suprachiasmatic nuclei to enhance oscillations in other proteins. (4) PER2 is ineffective at causing phase advances because it is not induced by light during the late night. (5) The clock is a limit cycle oscillator that shows characteristics of the Evening and Morning oscillator model.

KW - BMAL Rev-erbα

KW - CLOCK

KW - CRY

KW - Circadian Clock

KW - Eukaryotic transcription regulation

KW - Mathematical models

KW - PER

KW - Phase response curve

UR - http://www.scopus.com/inward/record.url?scp=4444289719&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4444289719&partnerID=8YFLogxK

U2 - 10.1016/j.jtbi.2004.04.041

DO - 10.1016/j.jtbi.2004.04.041

M3 - Article

C2 - 15363674

AN - SCOPUS:4444289719

SN - 0022-5193

VL - 230

SP - 533

EP - 539

JO - Journal of Theoretical Biology

JF - Journal of Theoretical Biology

IS - 4 SPEC. ISS.

ER -

Model based conjectures on mammalian clock controversies

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this