Model based conjectures on mammalian clock controversies

Daniel B. Forger, Charles S. Peskin

Research output: Contribution to journalArticle

Abstract

We explore some predictions of a previously developed detailed model of molecular timekeeping in mammals (Forger and Peskin, PNAS, 100:14806) in areas where our understanding of clock mechanisms are incomplete. It is conjectured that: (1) the clock's 24-h period depends on mRNA stability. (2) REV-ERBα suppresses and/or entrains rhythms in peripheral tissues by regulating CRY1 transcription. (3) CLK:BMAL1 oscillations are suppressed in the suprachiasmatic nuclei to enhance oscillations in other proteins. (4) PER2 is ineffective at causing phase advances because it is not induced by light during the late night. (5) The clock is a limit cycle oscillator that shows characteristics of the Evening and Morning oscillator model.

Original languageEnglish (US)
Pages (from-to)533-539
Number of pages7
JournalJournal of Theoretical Biology
Volume230
Issue number4 SPEC. ISS.
DOIs
StatePublished - Oct 21 2004

Keywords

  • BMAL Rev-erbα
  • CLOCK
  • CRY
  • Circadian Clock
  • Eukaryotic transcription regulation
  • Mathematical models
  • PER
  • Phase response curve

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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