Model-based iterative image reconstruction for photon migration tomography

Andreas H. Hielscher

    Research output: Contribution to journalConference articlepeer-review


    Currently available tomographic image reconstruction schemes for photon migration tomography (PMT) are mostly based on the limiting assumptions of small perturbations and a priori knowledge of the optical properties of a reference medium. In this work a model-based iterative image reconstruction (MOBIIR) method is presented, which does not require the knowledge of a reference medium or that the encountered heterogeneities are small perturbations. The code consists of three major parts: (1) A finite-difference, time-resolved, diffusion forward model is used to predict detector readings based on the spatial distribution of optical properties; (2) An objective function that describes the difference between predicted and measured data; (3) An updating scheme that uses the gradient of the objective function to provide subsequent guesses of the spatial distribution of the optical properties for the forward model. The reconstruction of these properties is completed, once a minimum of this objective function is found. After a review of the previously published mathematical background, the clinically relevant examples of breast cancer detection and brain imaging are discussed. It is shown that cysts and tumors can be distinguished using the MOBIIR technique, even in a heterogeneous background.

    Original languageEnglish (US)
    Pages (from-to)106-117
    Number of pages12
    JournalProceedings of SPIE - The International Society for Optical Engineering
    StatePublished - 1997
    EventComputational, Experimental, and Numerical Methods for Solving Ill-Posed Inverse Imaging Problems: Medical and Nonmedical Applications - San Diego, CA, United States
    Duration: Jul 30 1997Jul 30 1997


    • Diffusion
    • Image reconstruction
    • Photon migration
    • Tomography

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Computer Science Applications
    • Applied Mathematics
    • Electrical and Electronic Engineering


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