Model studies on the active site of cytochrome P-450: An FeII-porphyrin carrying a strapped thiolate ligand

Alan R. Battersby; William Howson; Andrew D. Hamilton

doi:10.1039/C39820001266

Model studies on the active site of cytochrome P-450: An Fe^II-porphyrin carrying a strapped thiolate ligand

Alan R. Battersby, William Howson, Andrew D. Hamilton

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

An Fe^II-porphyrin has been synthesised with a strap carrying a thiolate residue covalently bound across one face of the macrocycle; the spectroscopic properties of the carbon monoxide complex of this model system closely match those of the CO-complex of cytochrome P-450.

Original language	English (US)
Pages (from-to)	1266-1268
Number of pages	3
Journal	Journal of the Chemical Society - Series Chemical Communications
Issue number	21
DOIs	https://doi.org/10.1039/C39820001266
State	Published - 1982

ASJC Scopus subject areas

Molecular Medicine

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title = "Model studies on the active site of cytochrome P-450: An FeII-porphyrin carrying a strapped thiolate ligand",

abstract = "An FeII-porphyrin has been synthesised with a strap carrying a thiolate residue covalently bound across one face of the macrocycle; the spectroscopic properties of the carbon monoxide complex of this model system closely match those of the CO-complex of cytochrome P-450.",

author = "Battersby, {Alan R.} and William Howson and Hamilton, {Andrew D.}",

note = "Funding Information: spectra of the strapped porphyrins show many interesting features which will be discussed in our full paper. of the macrocycle by attaching a second strap incorporating anthracene (cf. ref. 3). We thank the S.E.R.C. for financial support. ",

year = "1982",

doi = "10.1039/C39820001266",

language = "English (US)",

pages = "1266--1268",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T2 - An FeII-porphyrin carrying a strapped thiolate ligand

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AU - Howson, William

AU - Hamilton, Andrew D.

N1 - Funding Information: spectra of the strapped porphyrins show many interesting features which will be discussed in our full paper. of the macrocycle by attaching a second strap incorporating anthracene (cf. ref. 3). We thank the S.E.R.C. for financial support.

PY - 1982

Y1 - 1982

N2 - An FeII-porphyrin has been synthesised with a strap carrying a thiolate residue covalently bound across one face of the macrocycle; the spectroscopic properties of the carbon monoxide complex of this model system closely match those of the CO-complex of cytochrome P-450.

AB - An FeII-porphyrin has been synthesised with a strap carrying a thiolate residue covalently bound across one face of the macrocycle; the spectroscopic properties of the carbon monoxide complex of this model system closely match those of the CO-complex of cytochrome P-450.

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Model studies on the active site of cytochrome P-450: An Fe^II-porphyrin carrying a strapped thiolate ligand

Abstract

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