Modeling Adipogenesis: Current and Future Perspective

Hisham F. Bahmad, Reem Daouk, Joseph Azar, Jiranuwat Sapudom, Jeremy C.M. Teo, Wassim Abou-Kheir, Mohamed Al-Sayegh

Research output: Contribution to journalReview articlepeer-review

Abstract

Adipose tissue is contemplated as a dynamic organ that plays key roles in the human body. Adipogenesis is the process by which adipocytes develop from adipose-derived stem cells to form the adipose tissue. Adipose-derived stem cells' differentiation serves well beyond the simple goal of producing new adipocytes. Indeed, with the current immense biotechnological advances, the most critical role of adipose-derived stem cells remains their tremendous potential in the field of regenerative medicine. This review focuses on examining the physiological importance of adipogenesis, the current approaches that are employed to model this tightly controlled phenomenon, and the crucial role of adipogenesis in elucidating the pathophysiology and potential treatment modalities of human diseases. The future of adipogenesis is centered around its crucial role in regenerative and personalized medicine.

Original languageEnglish (US)
JournalCells
Volume9
Issue number10
DOIs
StatePublished - Oct 20 2020

Keywords

  • adipogenesis
  • adipose-derived stem cells
  • modeling
  • organoids
  • preadipocytes

ASJC Scopus subject areas

  • Medicine(all)

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