Modeling gaze position-dependent opsoclonus

Lance M. Optican, Janet C. Rucker, John Ross Rizzo, Todd E. Hudson

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Opsoclonus/flutter (O/F) is a rare disorder of the saccadic system. Previously, we modeled O/F that developed in a patient following abuse of anabolic steroids. That model, as in all models of the saccadic system, generates commands to make a change in eye position. Recently, we saw a patient who developed a unique form of opsoclonus following a concussion. The patient had postsaccadic ocular flutter in both directions of gaze, and opsoclonus during fixation and pursuit in the left hemifield. A new model of the saccadic system is needed to account for this gaze-position dependent O/F. We started with our prior model, which contains two key elements, mutual inhibition between inhibitory burst neurons on both sides and a prolonged reactivation time of the omnipause neurons (OPNs). We included new inputs to the OPNs from the nucleus prepositus hypoglossi and the frontal eye fields, which contain position-dependent neurons. This provides a mechanism for delaying OPN reactivation, and creating a gaze-position dependence. A simplified pursuit system was also added, the output of which inhibits the OPNs, providing a mechanism for gaze-dependence during pursuit. The rest of the model continues to generate a command to change eye position.

    Original languageEnglish (US)
    Title of host publicationProgress in Brain Research
    EditorsStefano Ramat, Aasef G. Shaikh
    PublisherElsevier B.V.
    Pages35-61
    Number of pages27
    ISBN (Print)9780444642547
    DOIs
    StatePublished - 2019

    Publication series

    NameProgress in Brain Research
    Volume249
    ISSN (Print)0079-6123
    ISSN (Electronic)1875-7855

    Keywords

    • Model
    • Opsoclonus
    • Saccade
    • Smooth pursuit

    ASJC Scopus subject areas

    • Neuroscience(all)

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  • Cite this

    Optican, L. M., Rucker, J. C., Rizzo, J. R., & Hudson, T. E. (2019). Modeling gaze position-dependent opsoclonus. In S. Ramat, & A. G. Shaikh (Eds.), Progress in Brain Research (pp. 35-61). (Progress in Brain Research; Vol. 249). Elsevier B.V.. https://doi.org/10.1016/bs.pbr.2019.01.002