@inproceedings{d1b75a89e22a46179890904ae3d43c59,
title = "Modeling longitudinal MRI changes in populations using a localized, information-theoretic measure of contrast",
abstract = "Longitudinal MR imaging during early brain development provides important information about growth patterns and the development of neurological disorders. We propose a new framework for studying brain growth patterns within and across populations based on MRI contrast changes, measured at each time point of interest and at each voxel. Our method uses regression in the LogOdds space and an information-theoretic measure of distance between distributions to capture contrast in a manner that is robust to imaging parameters and without requiring intensity normalization. We apply our method to a clinical neuroimaging study on early brain development in autism, where we obtain a 4D spatiotemporal model of contrast changes in multimodal structural MRI.",
keywords = "Contrast, Kullback-Leibler, longitudinal MRI, regression",
author = "Avantika Vardhan and Marcel Prastawa and Anuja Sharma and Joseph Piven and Guido Gerig",
year = "2013",
doi = "10.1109/ISBI.2013.6556794",
language = "English (US)",
isbn = "9781467364546",
series = "Proceedings - International Symposium on Biomedical Imaging",
pages = "1396--1399",
booktitle = "ISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging",
note = "2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013 ; Conference date: 07-04-2013 Through 11-04-2013",
}