TY - JOUR
T1 - Modeling of spontaneous activity in developing spinal cord using activity-dependent depression in an excitatory network
AU - Tabak, Joël
AU - Senn, Walter
AU - O'Donovan, Michael J.
AU - Rinzel, John
PY - 2000/4/15
Y1 - 2000/4/15
N2 - Spontaneous episodic activity is a general feature of developing neural networks. In the chick spinal cord, the activity comprises episodes of rhythmic discharge (duration 5-90 sec; cycle rate 0.1-2 Hz) that recur every 2-30 min. The activity does not depend on specialized connectivity or intrinsic bursting neurons and is generated by a network of functionally excitatory connections. Here, we develop an idealized, qualitative model of a homogeneous, excitatory recurrent network that could account for the multiple time-scale spontaneous activity in the embryonic chick spinal cord. We show that cycling can arise from the interplay between excitatory connectivity and fast synaptic depression. The slow episodic behavior is attributable to a slow activity-dependent network depression that is modeled either as a modulation of cellular excitability or as synaptic depression. Although the two descriptions share many features, the model with a slow synaptic depression accounts better for the experimental observations during blockade of excitatory synapses.
AB - Spontaneous episodic activity is a general feature of developing neural networks. In the chick spinal cord, the activity comprises episodes of rhythmic discharge (duration 5-90 sec; cycle rate 0.1-2 Hz) that recur every 2-30 min. The activity does not depend on specialized connectivity or intrinsic bursting neurons and is generated by a network of functionally excitatory connections. Here, we develop an idealized, qualitative model of a homogeneous, excitatory recurrent network that could account for the multiple time-scale spontaneous activity in the embryonic chick spinal cord. We show that cycling can arise from the interplay between excitatory connectivity and fast synaptic depression. The slow episodic behavior is attributable to a slow activity-dependent network depression that is modeled either as a modulation of cellular excitability or as synaptic depression. Although the two descriptions share many features, the model with a slow synaptic depression accounts better for the experimental observations during blockade of excitatory synapses.
KW - Depression
KW - Developing spinal network
KW - Oscillations
KW - Rate model
KW - Recurrent excitation
KW - Spontaneous activity
UR - http://www.scopus.com/inward/record.url?scp=0034655174&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034655174&partnerID=8YFLogxK
U2 - 10.1523/jneurosci.20-08-03041.2000
DO - 10.1523/jneurosci.20-08-03041.2000
M3 - Article
C2 - 10751456
AN - SCOPUS:0034655174
SN - 0270-6474
VL - 20
SP - 3041
EP - 3056
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 8
ER -