Modeling of the hemodynamics in the feet of patients with peripheral artery disease

A. Marone, J. W. Hoi, M. A. Khalil, H. K. Kim, G. Shrikhande, R. Dayal, D. R. Bajakian, A. H. Hielscher

    Research output: Contribution to journalArticlepeer-review

    Abstract

    To simulate the hemodynamic effects in the feet in response to a thigh cuff occlusion, we have developed a multi-compartmental model in which the circulatory system for the leg is represented by its electrical equivalents. Dynamic vascular optical tomographic imaging data previously obtained from 20 patients with peripheral artery disease (PAD) and 20 healthy subjects is used to test the model. Analyzing the clinical data with the support of the model yields diagnostic specificity and sensitivity in the 90-95% range, significantly higher than previously reported.

    Original languageEnglish (US)
    Pages (from-to)657-669
    Number of pages13
    JournalBiomedical Optics Express
    Volume10
    Issue number2
    DOIs
    StatePublished - 2019

    ASJC Scopus subject areas

    • Biotechnology
    • Atomic and Molecular Physics, and Optics

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