Modeling of the hemodynamics in the feet of patients with peripheral artery disease

A. Marone; J. W. Hoi; M. A. Khalil; H. K. Kim; G. Shrikhande; R. Dayal; D. R. Bajakian; A. H. Hielscher

doi:10.1364/BOE.10.000657

Modeling of the hemodynamics in the feet of patients with peripheral artery disease

A. Marone, J. W. Hoi, M. A. Khalil, H. K. Kim, G. Shrikhande, R. Dayal, D. R. Bajakian, A. H. Hielscher

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

To simulate the hemodynamic effects in the feet in response to a thigh cuff occlusion, we have developed a multi-compartmental model in which the circulatory system for the leg is represented by its electrical equivalents. Dynamic vascular optical tomographic imaging data previously obtained from 20 patients with peripheral artery disease (PAD) and 20 healthy subjects is used to test the model. Analyzing the clinical data with the support of the model yields diagnostic specificity and sensitivity in the 90-95% range, significantly higher than previously reported.

Original language	English (US)
Pages (from-to)	657-669
Number of pages	13
Journal	Biomedical Optics Express
Volume	10
Issue number	2
DOIs	https://doi.org/10.1364/BOE.10.000657
State	Published - 2019

ASJC Scopus subject areas

Biotechnology
Atomic and Molecular Physics, and Optics

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title = "Modeling of the hemodynamics in the feet of patients with peripheral artery disease",

abstract = "To simulate the hemodynamic effects in the feet in response to a thigh cuff occlusion, we have developed a multi-compartmental model in which the circulatory system for the leg is represented by its electrical equivalents. Dynamic vascular optical tomographic imaging data previously obtained from 20 patients with peripheral artery disease (PAD) and 20 healthy subjects is used to test the model. Analyzing the clinical data with the support of the model yields diagnostic specificity and sensitivity in the 90-95% range, significantly higher than previously reported.",

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AU - Marone, A.

AU - Hoi, J. W.

AU - Khalil, M. A.

AU - Kim, H. K.

AU - Shrikhande, G.

AU - Dayal, R.

AU - Bajakian, D. R.

AU - Hielscher, A. H.

PY - 2019

Y1 - 2019

N2 - To simulate the hemodynamic effects in the feet in response to a thigh cuff occlusion, we have developed a multi-compartmental model in which the circulatory system for the leg is represented by its electrical equivalents. Dynamic vascular optical tomographic imaging data previously obtained from 20 patients with peripheral artery disease (PAD) and 20 healthy subjects is used to test the model. Analyzing the clinical data with the support of the model yields diagnostic specificity and sensitivity in the 90-95% range, significantly higher than previously reported.

AB - To simulate the hemodynamic effects in the feet in response to a thigh cuff occlusion, we have developed a multi-compartmental model in which the circulatory system for the leg is represented by its electrical equivalents. Dynamic vascular optical tomographic imaging data previously obtained from 20 patients with peripheral artery disease (PAD) and 20 healthy subjects is used to test the model. Analyzing the clinical data with the support of the model yields diagnostic specificity and sensitivity in the 90-95% range, significantly higher than previously reported.

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JF - Biomedical Optics Express

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Modeling of the hemodynamics in the feet of patients with peripheral artery disease

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