TY - JOUR
T1 - Modeling plasma membrane and endoplasmic reticulum excitability in pituitary cells
AU - Rinzel, John
AU - Keizer, Joel
AU - Li, Yue Xian
N1 - Funding Information:
This work was partially supportedb y funds from the NationalS cienceF oun-dation grants BIR 9234381 and BIR 9300799( to J.K.) and the Agricultural ExperimenSt tationa t the Universityo f California,D avis.
PY - 1996/12
Y1 - 1996/12
N2 - The response of gonadotrophs to secretagogues involves dose-dependent, complex dynamic patterns of electrical activity and inositol 1, 4, 5- trisphosphate (Ins P3)-induced Ca2+ mobilization, including pulsatility and oscillations on multiple time scales from milliseconds to minutes. Detailed in vitro experiments have enabled the identification of key mechanisms that underlie the plasma membrane (PM) electrical excitability and endoplasmic reticulum (ER) calcium excitability. We summarize these findings and review computer simulations of a biophysical model that resynthesizes and couples these components and that reproduces quantitatively the observed time courses and dose-response characteristics, as well as effects of various pharmacological manipulations. The theory suggests that cytosolic calcium is the primary messenger in coordinating the PM and ER regenerative behaviors during ER depletion and refilling.
AB - The response of gonadotrophs to secretagogues involves dose-dependent, complex dynamic patterns of electrical activity and inositol 1, 4, 5- trisphosphate (Ins P3)-induced Ca2+ mobilization, including pulsatility and oscillations on multiple time scales from milliseconds to minutes. Detailed in vitro experiments have enabled the identification of key mechanisms that underlie the plasma membrane (PM) electrical excitability and endoplasmic reticulum (ER) calcium excitability. We summarize these findings and review computer simulations of a biophysical model that resynthesizes and couples these components and that reproduces quantitatively the observed time courses and dose-response characteristics, as well as effects of various pharmacological manipulations. The theory suggests that cytosolic calcium is the primary messenger in coordinating the PM and ER regenerative behaviors during ER depletion and refilling.
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U2 - 10.1016/S1043-2760(96)00194-4
DO - 10.1016/S1043-2760(96)00194-4
M3 - Article
C2 - 18406778
AN - SCOPUS:0030560927
SN - 1043-2760
VL - 7
SP - 388
EP - 393
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 10
ER -