TY - JOUR
T1 - Modeling the conductance and DNA blockade of solid-state nanopores
AU - Kowalczyk, Stefan W.
AU - Grosberg, Alexander Y.
AU - Rabin, Yitzhak
AU - Dekker, Cees
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/8/5
Y1 - 2011/8/5
N2 - We present measurements and theoretical modeling of the ionic conductance G of solid-state nanopores with 5-100nm diameters, with and without DNA inserted into the pore. First, we show that it is essential to include access resistance to describe the conductance, in particular for larger pore diameters. We then present an exact solution for G of an hourglass-shaped pore, which agrees very well with our measurements without any adjustable parameters, and which is an improvement over the cylindrical approximation. Subsequently we discuss the conductance blockade ΔG due to the insertion of a DNA molecule into the pore, which we study experimentally as a function of pore diameter. We find that ΔG decreases with pore diameter, contrary to the predictions of earlier models that forecasted a constant ΔG. We compare three models for ΔG, all of which provide good agreement with our experimental data.
AB - We present measurements and theoretical modeling of the ionic conductance G of solid-state nanopores with 5-100nm diameters, with and without DNA inserted into the pore. First, we show that it is essential to include access resistance to describe the conductance, in particular for larger pore diameters. We then present an exact solution for G of an hourglass-shaped pore, which agrees very well with our measurements without any adjustable parameters, and which is an improvement over the cylindrical approximation. Subsequently we discuss the conductance blockade ΔG due to the insertion of a DNA molecule into the pore, which we study experimentally as a function of pore diameter. We find that ΔG decreases with pore diameter, contrary to the predictions of earlier models that forecasted a constant ΔG. We compare three models for ΔG, all of which provide good agreement with our experimental data.
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U2 - 10.1088/0957-4484/22/31/315101
DO - 10.1088/0957-4484/22/31/315101
M3 - Article
C2 - 21730759
AN - SCOPUS:79960773714
VL - 22
JO - Nanotechnology
JF - Nanotechnology
SN - 0957-4484
IS - 31
M1 - 315101
ER -