A typical single-cell fuel cell is capable of producing less than one volt of direct current. Therefore, to produce the voltages required in most industrial applications, many individual fuel cells must typically be stacked together and connected electrically in series. Computational fluid dynamics (CFD) can be helpful to predict fuel-cell performance before a cell is actually built and tested. However, to perform a CFD simulation using a 3-dimensional model of an entire fuel-cell stack would require a considerable amount of time and multiprocessor computing capability that may not be available to the designer. To eliminate the need to model an entire multi-cell assembly, a study was conducted to determine the incremental effect on fuel-cell performance of adding individual solid-oxide fuel cells (SOFC) to a multi-fuel-cell stack. As part of this process, a series of simulations was conducted to establish a CFD-nodal density that would produce reasonably accurate results but that could also be used to create and analyze the relatively large models of the multi-cell stacks. Full 3-dimensional CFD models were then created of a single-cell SOFC and of SOFC stacks containing two, three, four, five and six cells. Values of the voltage produced when operating with various current densities, together with temperature distributions, were generated for each of these CFD models. By comparing the results from each of the simulations, adjustment factors were developed to permit single-cell CFD results to be modified to estimate the performance of stacks containing multiple fuel cells. The use of these factors could enable fuel-cell designers to predict multi-cell stack performance using a CFD model of only a single cell.